Plant Phenolics and Human Health : Biochemistry, Nutrition and Pharmacology »

Cesar G. Fraga is Professor of Physical Chemistry at the University of Buenos Aires, Argentina, and is associated with the Department of Nutrition at the University of California at Davis. Dr. Fraga is the recipient of numerous awards, has served as guest editor of periodical publications, and has taken leadership roles in different scientific societies. He has an extensive record of publications on the biochemical and physiological effects of phenolic compounds and their potential effects on human health.

A collection of current knowledge of phytochemicals and health

Interest in phenolic phytochemicals has increased as scientific studies indicate these compounds exhibit potential health benefits. With contributions from world leaders in this research area, Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology offers an essential survey of the current knowledge on the capacity of specific micronutrients present in ordinary diets to fight disease.

The coverage in this resource:

• Explains the presence and biochemical properties of phenolics present in fruits and vegetables, as well as in foods derived from their plant sources

• Provides biochemical explanations on how certain plant phenolics fight cardiovascular and neurodegenerative diseases, cancer, and other widespread pathologies

• Focuses on certain phenolics, e.g., flavonoids, stilbenes, and curcuminoids, and provides insights on the biochemical bases used to define their significance in the diet as well as their recommended consumption requirements and toxicity

Appropriate for graduate and upper-level undergraduate courses in human and animal nutrition, basic nutritional biology, physiology, pharmacology, and other health-related disciplines, Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology serves as both an invaluable supplementary classroom text and a self-teaching guide for professionals interested in defining the association between diet and health from classical, alternative, and complementary biomedical perspectives.

Preface vii

Contributors ix

1 Dietary Flavonoids and Phenolic Compounds Indu B. Jaganath Alan Crozier 1

2 Bioavailability of Flavanols and Phenolic Acids Laure Poquet Michael N Clifford Gary Williamson 51

3 Biochemical Actions of Plant Phenolics Compounds: Thermodynamic and Kinetic Aspects Cesar G. Fraga Gulcin Sagdicoglu Celep Monica Galleano 91

4 Flavonoids-Membrane Interactions: Consequences for Biological Actions Sandra V. Verstraeten Cesar G. Fraga Patricia I. Oteiza 107

5 The Biochemistry Behind the Potential Cardiovascular Protection by Dietary Flavonoids Wai Mun Loke Jonathan M. Hodgson Kevin D. Croft 137

6 Dietary Flavanols: Biochemical Basis of Short-Term and Longer-Term Vascular Responses Tankred Schewe Yvonne Steffen Elisabeth Kravets Helmut Sies 159

7 Green Tea Catechins: Anticancer Effects and Molecular Targets Naghma Khan Hasan Mukhtar 165

8 Flavonols: Metabolism, Bioavailability, and Health Impacts Junji Terao 185

9 Flavonols: Biochemistry Behind Cardiovascular Effects Francisco Pérez-Vizcaino Juan Duarte 197

10 Metabolism, Bioavailability, and Analysis of Dietary Isoflavones Adrian A. Franke Brunhild M. Halm Kerry Kakazu Xingnan Li 215

11 Phytoestrogens Up-regulate Antioxidant Genes Consuelo Borrás Jose Viña 239

12 Dietary Isoflavones: Cardiovascular Actions and Activation of Cellular Signalling Pathways Richard C. M. Siow Giovanni E. Mann 249

13 Bioavailability and Metabolism of Resveratrol Cristina Andres-Lacueva Mireia Urpi-Sarda Raul Zamora-Ros Rosa M. Lamuela-Raventos 265

14 Resveratrol: Biochemistry and Functions Samarjit Das Hannah R. Vasanthi Dipak K. Das 299

15 Resveratrol:The Biochemistry Behind its Anticancer Effects Joydeb K. Kundu Young-Joon Surh 331

16 Curcumin: The Biochemistry Behind Its Anticancer Effects Preetha Anand Ajaikumar B. Kunnumakkara Bharat B. Aggarwal 361

17 Plant Phenolic Compounds: Modulation of Cytoprotective Enzymes and Nrf2/ARE Signaling Siwang Yu Ka Lung Cheung Wenge Li Ah-Ng Kong 401

18 Phenolics in Aging and Neurodegenerative Disorders Vittorio Calabrese Marzia Perluigi Carolin Cornelius Raffaella Coccia Fabio Di Domenico Giovanni Pennisi Chiara Cini Albena T. Dinkova-Kostova 427

19 Natural Phenolics and Metal Metabolism in Neurodegenerative Diseases Baolu Zhao 453

20 Epidemiology behind Fruit and Vegetable Consumption and Cancer Risk with Focus on Flavonoids Marta Rossi Eva Negri Cristina Bosetti Claudio Pelucchi Carlo La Vecchia 471

21 Phenylpropanoid Metabolism in Plants: Biochemistry, Functional Biology, and Metabolic Engineering Alberto B. Landolino Douglas R. Cook 489

Index 565