Authors: Gail M. Wilkes
ISBN-13: 9780763772116, ISBN-10: 0763772119
Format: Paperback
Publisher: Jones & Barlett Learning
Date Published: December 2009
Edition: 1E
Targeted Cancer Therapy: A Handbook For Nurses Is An Essential Guide For Nurses Interested In The Latest Discoveries In Oncology. Covering The Most Recent Treatment Option Of Transforming Cancer Into A Chronic Illness, Targeted Cancer Therapy Provides Nurses With The Information They Need To Understand This And Future Developments In The Field. This Comprehensive But Easy-To-Understand Text Takes Nurses Through Foundational Concepts In Cell And Normal Biology That Are Crucial To Understanding Cancer And Targeted Therapy. Featuring Relevant Analogies And Easy-To-Follow Discussions On Malignant Transformation, Metastases, Cellular Pathways, And Toxicities, This One-Of-A-Kind Text Enables Nurses To Quickly Get Up To Speed On Key Topics And Develop Care Plans For Oncology Patients. Accessible, Comprehensive, Informative, Targeted Cancer Therapy Is A Must-Read For Every Oncology Nurse.
Reviewer:Margaret R Hurst, BSN(University of New Mexico Hospital)
Description:This book reviews all the major targeted therapies currently used to treat patients with cancer.
Purpose:The purpose, as noted in the introduction, is to further educate nurses who work with targeted cancer therapies on how these drugs work in the context of the emerging knowledge in the field. This book is needed to help nurses understand how these medications work and how to manage side effects.
Audience:Nurses working with cancer patients are the intended audience. The author is an oncology clinical instructor.
Features:The book covers all the major classes of targeted therapy from how they work to how to manage their side effects. It is extremely thorough and includes a useful glossary in the back. However, it presumes a level of knowledge of cell and molecular biology that many nurses do not have. It may be more useful for nurses who work in advanced practice roles who may have a more in-depth knowledge of biology.
Assessment:This is a good quality book, but it may be more suitable for advanced practice nurses than for most nurses currently working at the bedside. The subject is important, but the author seems to assume readers have a certain baseline knowledge that I do not believe many nurses working with these patients have.
Introduction v
Chapter 1 Cancer Biology, Signaling Pathways, and Malignant Transformation 1
Hallmarks of Cancer 1
Application of the Hallmarks of Cancer 2
Invasion and Metastasis 18
Epigenetics 30
Summary 34
References 34
Chapter 2 Targeted Cancer Therapy: External and Internal Signaling Pathway Targets 39
Monoclonal Antibodies 42
Membrane-Bound Receptor Kinases (e.g., EGFR, HER2, HGF/c-Met, IGFR pathways) 73
Hepatocyte Growth Factor (HGF/c-Met) Receptor Pathway Targets 125
Insulin-like Growth Factor Receptor Pathway Targets 127
Intracellular Signaling Kinases (e.g., src, P13k/Akt/mTOR; MAPK; sonic hedgehog pathways) 128
Protein Kinase Signaling Pathways 129
Protein Kinase Inhibitors 136
Protein Dynamics: Heat Shock Proteins and Ubiquitin-Proteasome Inhibitors 150
Epigenetic Abnormalities (DNA Methyltransferase and Histone Deacetylase) 160
Tumor Vasculature and Microenvironment 175
References 175
Chapter 3 Tumor Vasculature 185
Targeting Angiogenesis 185
Antiangiogenic Drug Therapy 194
Hypoxia-Inducible Factor, mTOR, and Angiogenesis 198
Nursing Considerations and Drug Information 203
References 250
Chapter 4 Targeting the Microenvironment: Bone Metastasis, Apoptosis, DNA Repair, and Mitosis 255
Bone Metastasis 255
Pharmacologic Management 262
Targeting Apoptosis 271
DNA Repair Gene Mutations: Opportunities from Synthetic Lethality 277
Mitotic Kinase Inhibitors 280
Summary 284
References 284
Chapter 5 Challenges in Caring for Patients Receiving Targeted Therapy 289
Drag Interactions: Focus on the P450 Microenzyme System 289
Encouraging Patient Adherence and Persistence 302
References 310
Glossary 313
Index 329