Structure-Based Study of Viral Replication (with Cd-Rom) »

This book addresses the innovative themes in characterizing the cellular membrane platforms and intracellular networking, as well as the architectural aspects of cell compartments mediated by the entry and replication cycles of viruses. The instrumentation of modern molecular and cellular biology provides a potent array of wave packets to image, detect and manipulate major dynamics of macromolecular and subviral assemblies as in the host cellular context.

The book includes case studies presented with highly coherent and structured illuminations, including microscopy, spectroscopy and scanning probes. The compilation and integration of the methodology provides time-resolved observations on the reactivity of structures from near-atomic resolution to various molecular or cellular levels of descriptors. The book provides a broad introduction to the various fascinating virus systems and may be used as an advanced textbook by graduate students in biomedicine. It provides adequate background material to explore further the research problems of epidemics in the 21st century.

List of Contributors     ix
Human Rhinovirus Cell Entry and Uncoating   Renate Fuchs   Dieter Blaas     1
Role of Lipid Microdomains in Influenza Virus Multiplication   Makoto Takeda     43
Functions of Integrin [alpha]2[beta]1, A Collagen Receptor, in the Internalization of Echovirus 1   Varpu Marjomaki   Mikko Huhtala   Mikko Karjalainen   Timo Hyypia   Jyrki Heino     63
Entry Mechanism of Murine and SARS Coronaviruses - Similarity and Dissimilarity   Fumihiro Taguchi     77
Hepatitis Viruses, Signaling Events and Modulation of the Innate Host Response   Syed Mohammad Moin   Anindita Kar-Roy   Shahid Jameel     91
Virus-Cell Interaction of HCV   Hideki Tani   Yasumasa Komoda   Chang-kwang Limn   Kensuke Suzuki   Kohji Moriishi   Tatsuo Miyamura   Yoshiharu Matsuura     125
RNA Replication of Hepatitis C Virus   Hideki Aizaki   Tetsuro Suzuki     151
Structure and Dynamics in Viral RNA Packaging   Thorsten Dieckmann   Marta Zumwalt     173
Rational Design of Viral Protein Structures with Predetermined Immunological Properties   James Lara   Yury Khudyakov     199
Bioinformatics Resources for the Study of Viruses at the Virginia Bioinformatics Institute   Anjan Purkayastha   Oswald Crasta   J. Dana Eckart   Michael Czar   X. J. Meng   Joao Setubal   Bruno Sobral     267
Virus Architecture Probed by Atomic Force Microscopy   A. J. Malkin   Yu. G. Kuznetsov   M. Plomp   A. McPherson     289
Filovirus Assembly and Budding   Takeshi Noda   Yoshihiro Kawaoka     311
Challenges in Designing HIV Env Immunogens for Developing a Vaccine   Indresh K. Srivastava   R. Holland Cheng     327
Insights into the Caliciviridae Family   Grant Hansman     381
Mathematical Approaches for Stoichiometric Quantification in Studies of Viral Assembly and DNA Packaging   Peixuan Guo   Jeremy Hall   Tae Jin Lee     401
Virus-like Particles of Fish Nodavirus   Chan-Shing Lin     449
The Assembly of the Double-Layered Capsids of Phytoreoviruses   Toshihiro Omura   Naoyuki Miyazaki   Hisashi Naitow   R. Holland Cheng   Tomitake Tsukihara   Atsushi Nakagawa     463
Structure and Assembly of Human Herpesviruses: New Insights From Cryo-Electron Microscopy and Tomography   Z. Hong Zhou   Pierrette Lo     483
Human Papillomavirus Type 16 Capsid Proteins: Immunogenicity and Possible Use as Prophylactic Vaccine Antigens   Tadahito Kanda   Kei Kawana   Hiroyuki Yoshikawa     517
Chimeric Recombinant Hepatitis E Virus-like Particles Presenting Foreign Epitopes as a Novel Vector of Vaccine by Oral Administration   Yasuhiro Yasutomi     539
Nucleocapsid Protein of Hantaviruses (Bunyaviridae): Structure and Functions   Alexander Plyusnin   Vibhor Kumar   Olli Vapalahti   Peter Engelhardt     553
Astrovirus Replication: An Overview   Susana Guix   Albert Bosch   Rosa M. Pinto     571
DNA Vaccines against Viruses   Britta Wahren   Margaret Liu     597
Life Cycles of Polyomaviridae - DNA Tumor Virus   Masaaki Kawano   Hiroshi Handa   R. Holland Cheng     609
Index     631