Structure-Based Study of Viral Replication (with Cd-Rom) »

This book addresses the innovative themes in characterizing the cellular membrane platforms and intracellular networking, as well as the architectural aspects of cell compartments mediated by the entry and replication cycles of viruses. The instrumentation of modern molecular and cellular biology provides a potent array of wave packets to image, detect and manipulate major dynamics of macromolecular and subviral assemblies as in the host cellular context.

The book includes case studies presented with highly coherent and structured illuminations, including microscopy, spectroscopy and scanning probes. The compilation and integration of the methodology provides time-resolved observations on the reactivity of structures from near-atomic resolution to various molecular or cellular levels of descriptors. The book provides a broad introduction to the various fascinating virus systems and may be used as an advanced textbook by graduate students in biomedicine. It provides adequate background material to explore further the research problems of epidemics in the 21st century.

Ch. 1 Human Rhinovirus Cell Entry and Uncoating Renate Fuchs Fuchs, Renate Dieter Blaas Blaas, Dieter 1

Ch. 2 Role of Lipid Microdomains in Influenza Virus Multiplication Makota Takeda Takeda, Makota 43

Ch. 3 Functions of Integrin [alpha]2[beta1] A Collagen Receptor, in the Internalization of Echovirus 1 Varpu Marjomaki Marjomaki, Varpu Mikko Hubtala Hubtala, Mikko Mikko Karjalainen Karjalainen, Mikko Timo Hyypia Hyypia, Timo Jyrki Heino Heino, Jyrki 63

Ch. 4 Entry Mechanism of Murine and SARS Coronaviruses - Similarity and Dissimilarity Fumihiro Taguchi Taguchi, Fumihiro 77

Ch. 5 Hepatitis Viruses, Signaling Events and Modulation of the Innate Host Response Syed Mohammad Moin Moin, Syed Mohammad Anindita Kar-Roy Kar-Roy, Anindita Shahid Jameel Jameel, Shahid 91

Ch. 6 Virus-Cell Interaction of HCV Hideki Tani Tani, Hideki Yasumasa Komoda Komoda, Yasumasa Ghang-kwang Limn Limn, Ghang-kwang Kensuke Suzuki Suzuki, Kensuke Kohji Moriishi Moriishi, Kohji Tatsuo Miyamura Miyamura, Tatsuo Yoshiharu Matsuura Matsuura, Yoshiharu 125

Ch. 7 RNA Replication of Hepatitis C Virus 1 Hideki Aizaki Aizaki, Hideki Tetsuro Suzuki Suzuki, Tetsuro 151

Ch. 8 Structure and Dynamics in Viral RNA Packaging Thorsten Dieckmann Dieckmann, Thorsten Marta Zumwalt Zumwalt, Marta 173

Ch. 9 Rational Design of Viral Protein Structures with Predetermined Immunological Properties James Lara Lara, James Yury Khudyakov Khudyakov, Yury 199

Ch. 10 Bioinformatics Resources for the Study of Viruses at the Virginia Bioinformatics Institute Anjan Purkayastha Purkayastha, Anjan Oswald Crasta Crasta, Oswald J. Dana Eckart Eckart, J. Dana Michael Czar Czar, Michael X. J. Meng Meng, X. J. Joan Setubal Setubal, JoanBruno Sobral Sobral, Bruno 267

Ch. 11 Virus Architecture Probed by Atomic Force Microscopy A. J. Malkin Malkin, A. J. Yu. G. Kuznetsov Kuznetsov, Yu. G. M. Plomp Plomp, M. A. McPherson McPherson, A. 289

Ch. 12 Filovirus Assembly and Budding Takeshi Noda Noda, Takeshi Yoshihiro Kawaoka Kawaoka, Yoshihiro 311

Ch. 13 Challenges in Designing HIV Env Immunogens for Developing a Vaccine Indresh K. Srivastava Srivastava, Indresh K. R. Holland Cheng Cheng, R. Holland 327

Ch. 14 Insights into the Caliciviridae Family Grant Hansman Hansman, Grant 381

Ch. 15 Mathematical Approaches for Stoichiometric Quantification in Studies of Viral Assembly and DNA Packaging Peixuan Guo Guo, Peixuan Jeremy Hall Hall, Jeremy Tae Jin Lee Lee, Tae Jin 401

Ch. 16 Virus-like Particles of Fish Nodavirus Chan-Shing Lin Lin, Chan-Shing 449

Ch. 17 The Assembly of the Double-Layered Capsids of Phytoreoviruses Toshihiro Omura Omura, Toshihiro Naoyuki Miyazaki Miyazaki, Naoyuki Hisashi Naitow Naitow, Hisashi R. Holland Cheng Cheng, R. Holland Tomitake Tsukihara Tsukihara, Tomitake Atsushi Nakagawa Nakagawa, Atsushi 463

Ch. 18 Structure and Assembly of Human Herpesviruses: New Insights From Cryo-Electron Microscopy and Tomography Z. Hong Zhou Zhou, Z. Hong Pierrette Lo Lo, Pierrette 483

Ch. 19 Human Papillomavirus Type 16 Capsid Proteins: Immunogenicity and Possible Use as Prophylactic Vaccine Antigens Tadahito Kanda Kanda, Tadahito Kei Kawana Kawana, Kei Hiroyuki Yoshikawa Yoshikawa, Hiroyuki 517

Ch. 20 Chimeric Recombinant Hepatitis E Virus- like Particles Presenting Foreign Epitopes as a Novel Vector of Vaccine by Oral Administration Yasuhiro Yasutomi Yasutomi, Yasuhiro 539

Ch. 21 Nucleocapsid Protein of Hantaviruses (Bunyaviridae): Structure and Functions Alexander Plyusnin Plyusnin, Alexander Vibhor Kumar Kumar, Vibhor Olli Vapalahti Vapalahti, Olli Peter Engelhardt Engelhardt, Peter 553

Ch. 22 Astrovirus Replication: An Overview Susana Guix Guix, Susana Albert Bosch Bosch, Albert Rosa M. Pinto Pinto, Rosa M. 571

Ch. 23 DNA Vaccines against Viruses Britta Wahren Wahren, Britta Margaret Liu Liu, Margaret 597

Ch. 24 Life Cycles of Polyomaviridac - DNA Tumor Virus Masaaki Kawano Kawano, Masaaki Hiroshi Handa Handa, Hiroshi R. Holland Cheng Cheng, R. Holland 609

Index 631