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Neuropsychopharmacology: The Fifth Generation of Progress » (5th Edition)

Book cover image of Neuropsychopharmacology: The Fifth Generation of Progress by Kenneth L. Davis

Authors: Kenneth L. Davis (Editor), Dennis Charney (Editor), Joseph T. Coyle (Editor), Charles Nemeroff
ISBN-13: 9780781728379, ISBN-10: 0781728371
Format: Hardcover
Publisher: Lippincott Williams & Wilkins
Date Published: February 2002
Edition: 5th Edition

Author Biography: Kenneth L. Davis

Book Synopsis

Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of all neuropsychiatric disorders. Nine sections focus on specific groups of disorders, covering clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation.
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Booknews

This official publication of the American College of Neuropsychopharmacology details advances in both the basic science and clinical application of recent research in the field, and demonstrates the prospects for even greater future advances. The 134 contributions by clinical experts and researchers discuss neurotransmitter and signal transduction; emerging methods in molecular biology and genetics; emerging imaging technologies and their application to psychiatric research; drug discovery and evaluation; developmental, schizophrenic, anxiety and stress, affective, substance use, impulsive and compulsive, movement, paroxysmal, chronobiology and sleep disorders; and Alzheimers and other dementias. Edited by Davis (Mount Sinai School of Medicine), Dennis Charney (National Institute of Mental Health), Joseph T. Coyle (Harvard Medical School), and Charles Nemeroff (Emory U. School of Medicine). Annotation c. Book News, Inc., Portland, OR (booknews.com)

	Contributors	xi
	Preface	xxi
Section 1	Neurotransmitter and Signal Transduction	1
1	Acetylcholine	3
2	Serotonin	15
3	Opioid Peptides and Their Receptors: Overview and Function in Pain Modulation	35
4	Norepinephrine	47
5	Regulation of G Protein-Coupled Receptors by Phosphorylation and Endocytosis	59
6	The Diverse Roles of L-Glutamic Acid in Brain Signal Transduction	71
7	Corticotropin-Releasing Factor: Physiology, Pharmacology and Role in Central Nervous System Disorders	91
8	Neurogenesis in Adult Brain	110
9	Dopamine	120
10	Astrocytes	133
11	Synaptic Plasticity	147
12	GABA	159
13	Substance P and Related Tachykinins	169
14	Histamine	179
15	Purinergic Neurotransmission	191
16	Neurotrophic Factors and Intracellular Signal Transduction Pathways	207
17	Regulation of Gene Expression	217
Section 2	Emerging Methods in Molecular Biology and Genetics	229
18	Using Human Genomics to Advance Neuropyschopharmacology	231
19	Gene Targeting and Transgenic Technologies	241
20	Gene Delivery Into the Brain Using Viral Vectors	253
21	Neuropsychopharmacology of Worms and Flies	263
22	Beyond Binding: Molecular and Cell Biological Approaches to Studying G Protein-Coupled Receptors	275
23	Applying Functional Genomics to Neuropsychopharmacology	291
Section 3	Emerging Imaging Technologies and Their Application to Psychiatric Research	299
24	Automated 3D Analysis of Large Brain MRI Databases	301
25	In Vivo Magnetic Resonance Spectroscopy Studies of the Glutamate and GABA Neurotransmitter Cycles and Functional Neuroenergetics	315
26	The Spatial, Temporal, and Interpretive Limits of Functional MRI	343
27	Diffusion Tensor Imaging	357
28	Activation Paradigms in Affective and Cognitive Neuroscience: Probing the Neuronal Circuitry Underlying Mood and Anxiety Disorders	373
29	Interactions Among Neuronal Systems Assessed With Functional Neuroimaging	383
30	Measuring Brain Connectivity with Functional Imaging and Transcranial Magnetic Stimulation (TMS)	393
31	In Vivo Molecular Imaging: Ligand Development and Research Applications	411
32	Event-Related Potentials and Magnetic Fields in the Human Brain	427
Section 4	Drug Discovery and Evaluation	441
33	The Role of Preclinical Models in the Development of Psychotropic Drugs	445
34	Proof of Concept: Functional Models for Drug Development in Humans	457
35	Ethical Aspects of Neuropsychiatric Research with Human Subjects	475
36	Regulatory Issues	485
37	Pharmacogenomics and Personalized Therapeutics in Psychiatry	495
38	Pharmacokinetics, Pharmacodynamics, and Drug Disposition	507
39	The Role of Pharmaceuticals in Mental Health Care Outcomes	525
40	Issues in Clinical Trial Designs	537
Section 5	Disorders of Development	547
41	The Molecular and Cellular Genetics of Autism	549
42	Current and Emerging Therapeutics of Autistic Disorder and Related Pervasive Developmental Disorders	565
43	Pathophysiology of Attention Deficit Hyperactivity Disorder	577
44	Learning Disorders	597
45	Psychosis in Childhood and Its Management	613
46	Behavioral Phenotypes of Neurodevelopmental Disorders: Portals into the Developing Brain	625
Section 6	Schizophrenia and Related Disorders	639
47	Schizophrenia: Course Over the Lifetime	641
48	Neurocognitive Functioning in Patients with Schizophrenia: An Overview	657
49	Molecular and Population Genetics of Schizophrenia	671
50	Animal Models Relevant to Schizophrenia Disorders	689
51	Endophenotypes in Studies of the Genetics of Schizophrenia	703
52	Neurochemistry of Schizophrenia: Glutamatergic Abnormalities	717
53	Neural Circuitry Approaches to Understanding the Pathophysiology of Schizophrenia	729
54	Functional Neuroimaging in Schizophrenia	745
55	Structural Magnetic Resonance Imaging in Schizophrenia	757
56	Therapeutics of Schizophrenia	775
57	The Economics of the Treatment of Schizophrenia	809
58	Mechanism of Action of Atypical Antipsychotic Drugs	819
59	Neurochemical and Neuropharmacological Imaging in Schizophrenia	833
Section 7	Anxiety and Stress Disorders	857
60	Anxiety and Stress Disorders: Course Over the Lifetime	859
61	Genetic and Other Vulnerability Factors For Anxiety and Stress Disorders	867
62	Animal Models and Endophenotypes of Anxiety and Stress Disorders	883
63	The Neurobiological Basis of Anxiety Disorders	901
64	Neural Circuitry of Anxiety and Stress Disorders	931
65	Structural and Functional Imaging of Anxiety and Stress Disorders	953
66	Current and Emerging Therapeutics of Anxiety and Stress Disorders	967
67	The Economic Burden of Anxiety and Stress Disorders	981
68	Mechanisms of Action of Anxiolytics	993
Section 8	Affective Disorders	1007
69	The Course of Depression	1009
70	Risk Factors for Major Depression and Bipolar Disorder	1017
71	Bipolar Disorders: Review of Molecular Genetic Linkage Studies	1027
72	Molecular and Cellular Mechanisms in Depression	1039
73	Neurocircuitry of Mood Disorders	1051
74	Structural and Functional Imaging of Affective Disorders	1065
75	Current and Emerging Therapeutics for Depression	1081
76	Electroconvulsive Therapy: Sixty Years of Progress and a Comparison with Transcranial Magnetic Stimulation and Vagal Nerve Stimulation	1097
77	Current and Emerging Treatments for Acute Mania and Long Term Prophylaxis for Bipolar Disorder	1109
78	Cost Effectiveness of the Newer Generation of Antidepressants	1119
79	Mechanism of Action of Antidepressants and Mood-Stabilizers	1139
80	Hormonal and Gender Influences on Mood Regulation	1165
81	Depression and the Medically Ill	1179
Section 9	Alzheimers and Other Dementias	1187
82	Alzheimer's Disease: From Earliest Symptoms to End Stage	1189
83	Molecular Genetics of Alzheimer's Disease	1199
84	Transgenic Mouse Models of Alzheimer's Disease	1215
85	Cell and Molecular Neuropathology of Alzheimer's Disease	1221
86	Structural and Functional Brain Imaging of Alzheimer's Disease	1231
87	Current and Experimental Therapeutics of Alzheimer's Disease	1243
88	Alzheimer's Disease: Treatment of Noncognitive Behavioral Abnormalities	1253
89	Cost-Effectiveness of Therapeutics for Alzheimer's Disease	1267
90	Neuropsychiatric Manifestations of HIV-1 Infection and AIDS	1281
91	Dementia with Lewy Bodies	1301
92	Molecular Pathophysiology of Stroke	1317
93	Current and Experimental Treatment of Stroke	1327
94	Tau Protein and Tauopathy	1339
Section 10	Substance use Disorders	1355
95	Neurocircuitry of Addiction	1357
96	Molecular and Cellular Bilogy of Addiction	1367
97	Recent Advances in Animal Models of Drug Addiction	1381
98	Vulnerability Factors for Alcoholism	1399
99	Molecular and Cellular Genetics of Alcohol Addiction	1413
100	Ethanol Abuse, Dependence, and Withdrawal: Neurobiology and Clinical Implications	1423
101	Alcoholism Pharmacotherapy	1445
102	Pathophysiology and Treatment of Cocaine Dependence	1461
103	Application of Imaging Technologies in the Investigation of Drug Addiction	1475
104	Molecular and Cellular Neurobiology and Pathophysiology of Opiate Addiction	1491
105	Current and Experimental Therapeutics for the Treatment of Opioid Addiction	1507
106	Marijuana	1519
107	Therapeutics for Nicotine Addiction	1533
108	Psychedelic Drugs	1545
109	Epidemiology of Drug Dependence	1557
110	Neuroimaging of Cocaine Craving States: Cessation, Stimulant Administration, and Drug Cue Paradigms	1575
Section 11	Impulsive and Compulsive Disorders	1591
111	The Course and Clinical Features of Obsessive Compulsive Disorder	1593
112	The Pathophysiology and Genetics of Obsessive Compulsive Disorder	1609
113	Imaging and Neurocircuitry of OCD	1621
114	Current and Experimental Therapeutics of Obsessive-Compulsive Disorder	1647
115	The Behavioral Neuroscience of Eating	1665
116	Psychopharmacology of Eating Disorders	1675
117	Tourette's Syndrome and Related Tic Disorders	1685
118	Animal Models of Aggression	1699
119	Pathophysiology and Treatment of Aggression	1709
120	Pathological Gambling and Impulse Control Disorders	1725
121	Compulsive and Impulsive Aspects of Self-Injurious Behavior	1743
Section 12	Movement Disorders and Paroxysmal Disorders	1759
122	Neurocircuitry of Parkinson's Disease	1761
123	Pathophysiology of Parkinson's Disease	1781
124	Current and Experimental Therapeutics of Parkinson's Disease	1795
125	Huntington's Disease	1817
126	Clinical Course and Cellular Pathology of Tardive Dyskinesia	1831
127	Temporal Lobe Epilepsy: Renewed Emphasis on Extrahippocampal Areas	1843
Section 13	Chronobiology and Sleep Disorders	1857
128	Basic Mechanisms of Sleep: New Evidence on the Neuroanatomy and Neuromodulation of the NREM-REM Cycle	1859
129	Circadian Phase Sleep and Mood Disorders	1879
130	Sleep Loss and Sleepiness: Physiological and Neurobehavioral Effects	1895
131	Pathophysiological and Pharmacological Aspects of the Sleep Disorder Narcolepsy	1907
132	Basic Mechanisms of Sedative/Hypnotics	1923
133	Current and Experimental Therapeutics of Insomnia	1931
134	Sleep Disturbances Associated with Neuropsychiatric Disease	1945
	Subject Index	1961