Nanotechnology in Cancer Therapeutics »

While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance for Nanotechnology in Cancer in 2004 and pledged $144.3 million in funding over the next five years.

Edited by one of the most dynamic pioneers in the field, Nanotechnology for Cancer Therapy focuses on those nanoscientific and nanotechnological strategies that are evolving as the most promising for the imaging and treatment of cancer. Among the various approaches considered, nanotechnology offers great possibilities for the targeted delivery of drugs and genes to tumor sites and the ultimate replacement of those chemotherapeutic agents so compromised by side effects.

Within this volume, the expertise of world-renowned academic and industrial researchers is brought together to provide a comprehensive treatise. Composed of 38 chapters, the book is divided into 7 sections that cover -

SECTION 1 NANOTECHNOLOGY AND CANCER Introduction and Rationale for Nanotechnology in Cancer Therapy; Fredika M. Robertson and Mauro Ferrari Passive Targeting of Solid Tumors: Pathophysiological Principles and Physicochemical Aspects of Delivery Systems; S. M. Moghimi Active Targeting Strategies in Cancer with a Focus on Potential Nanotechnology Applications; Randall J. Mrsny Pharmacokinetics of Nanocarrier-Mediated Drug and Gene Delivery; Yuriko Higuchi, Shigeru Kawakami, and Mitsuru Hashida Multifunctional Nanoparticles for Cancer Therapy; Todd J. Harris, Geoffrey von Maltzahn, and Sangeeta N. Bhatia Neutron Capture Therapy of Cancer: Nanoparticles and High Molecular Weight Boron Delivery Agents; Gong Wu, Rolf F. Barth, Weilian Yang, Robert J. Lee, Werner Tjarks, Marina V. Backer, and Joseph M. Backer Preclinical Characterization of Engineered Nanoparticles Intended for Cancer Therapeutics; Anil K. Patri, Marina A. Dobrovolskaia, Stephan T. Stern, and Scott E. McNeil Nanotechnology: Regulatory Perspective for Drug Development in Cancer Therapeutics; N. Sadrieh and T. J. Miller SECTION 2 POLYMER CONJUGATES Polymeric Conjugates for Angiogenesis Targeted Tumor Imaging and Therapy; Amitava Mitra, Anjan Nan, Bruce R. Line, and Hamidreza Ghandehari Poly (L-Glutamic Acid): Efficient Carrier of Cancer Therapeutics and Diagnostics; Guodong Zhang, Edward F. Jackson, Sidney Wallace, and Chun Li Noninvasive Visualization of In Vivo Drug Delivery of Paramagnetic Polymer Conjugates with MRI; Zheng-Rong Lu, Yanli Wang, Furong Ye, Anagha Vaidya, and Eun-Kee Jeong SECTION 3 POLYMERIC NANOPARTICLES Polymeric Nanoparticles for Tumor-Targeted Drug Delivery; Tania Betancourt, Amber Doiron, and Lisa Brannon-Peppas Long-Circulating Polymeric Nanoparticles for Drug and Gene Delivery to Tumors; Sushma Kommareddy, Dinesh B. Shenoy, and Mansoor M. Amiji Biodegradable PLGA/PLA Nanoparticles for Anticancer Therapy; Sanjeeb K. Sahoo and Vinod Labhasetwar Poly (alkyl cyanoacrylate) Nanoparticles for Delivery of Anticancer Drugs; R. S. R. Murthy and L. Harivardhan Reddy Aptamers and Cancer Nanotechnology; Omid C. Farokhzad, Sangyong Jon, and Robert Langer SECTION 4 POLYMERIC MICELLES Polymeric Micelles for Formulation of Anticancer Drugs; Helen Lee, Patrick Lim Soo, Jubo Liu, Maok Butler, and Christine Allen PEO-Modified Poly (L-Amino Acid) Micelles for Drug Delivery; Afsaneh Lavasanifar, Xiuo-Bing Xiong, and Hamidreza Montazeri Aliabadi Hydrotropic Polymer Micelles for Cancer Therapeutics; Sang Cheon Lee, Kang Moo Huh, Tooru Ooy, and Kinam Park Tumor-Targeted Delivery of Sparingly-Soluble Anti-Cancer Drugs with Polymeric Lipid-Core Immunomicelles; Vladimir P. Torchilin Combined Cancer Therapy by Micellar-Encapsulated Drug and Ultrasound; Natalya Rapoport Polymeric Micelles Targeting Tumor pH3; Eun Seong Lee and You Han Bae cRGD-Encoded, MRI-Visible Polymeric Micelles for Tumor-Targeted Drug Delivery; Jinming Gao, Norased Nasongkla, and Chalermchai Khemtong Targeted Antisense Oligonucleotide Micellar Delivery Systems; Ji Hoon Jeong, Sun Hwa Kim, and Tae Gwan Park SECTION 5 DENDRITIC NANOCARRIERS Dendrimers as Drug and Gene Delivery Systems; Tae-Il Kim and Jong-Sang Park Dendritic Nanostructures for Cancer Therapy; Ashootosh V. Ambade, Elamprakash N. Savariar, and S. Thai Thayumanavan PEGylated Dendritic Nanoparticulate Carriers of Anti-Cancer Drug; D. Bhadra, S. Bhadra, and N. K. Jain Dendrimer Nanocomposites for Cancer Therapy; Lajos P. Balogh and Mohamed K. Khan SECTION 6 LIPOSOMES Applications of Liposomal Drug Delivery Systems to Cancer Therapy; Alberto A. Gabizon Positively-Charged Liposomes for Targeting Tumor Vasculature; Robert B. Campbell Cell Penetrating Peptide (CPP)-Modified Liposomal Nanocarriers for Intracellular Drug and Gene Delivery; Vladimir P. Torchilin RGD-Modified Liposomes for Tumor Targeting; S. P. Vyas Folate Receptor-Targeted Liposomes for Cancer Therapy; Xiaobin B. Zhao, Natarajan Muthusamy, John C. Byrd, and Robert J. Lee Nanoscale Drug Delivery Vehicles for Solid Tumors: A New Paradigm for Localized Drug Delivery Using Temperature Sensitive Liposomes; David Needham and Ana Ponce SECTION 7 OTHER LIPID NANOSTRUCTURES Nanoemulsions Formulations for Tumor-Targeted Delivery; Sandip B. Tiwari and Mansoor M. Amiji Solid Lipid Nanoparticles for Antitumor Drug Delivery; Ho Lun Wong, Yongqiang Li, Reina Bendayan, Mike Andrew Rauth, and Xiao Yu Wu Lipoprotein Nanoparticles as Delivery Vehicles for Anti-Cancer Agents; Andras G. Lacko, Maya Nair, and Watter J. McConathy DQAsomes as Mitochondria-Targeted Nano-Carriers for Anticancer Drugs; Shing-Ming Cheng, Sarathi V. Boddapati, Gerard G. M. D'Souza, and Volkmar Weissig