Authors: John A. Joule, Keith Mills
ISBN-13: 9781405193658, ISBN-10: 1405193654
Format: Hardcover
Publisher: Wiley, John & Sons, Incorporated
Date Published: June 2010
Edition: (Non-applicable)
John Joule is Emeritus Professor in the School of Chemistry, The University of Manchester, UK
Keith Mills spent 25 years in the Medicinal Chemistry and Development Chemistry departments at GlaxoSmithKline, Stevenage, UK, and is now an independent consultant.
Heterocyclic chemistry is a central part of organic chemistry and biochemistry. The term refers to a particular set of chemical structure characteristics, with many drugs and specialty chemicals, and most agrochemicals, containing these characteristics. Heterocyclic Chemistry by Joule & Mills has established itself as the premier textbook of heterocyclic chemistry, used by high level undergraduates, postgraduates and industrial researchers all over the world.
Heterocyclic Chemistry covers the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. It also includes more advanced material, making the book appropriate for postgraduate taught courses and to researchers, either at postgraduate degree level or those working with heterocyclic compounds in industry. Essential teaching material is collected in specific introductory chapters, explaining the principles of heterocyclic reactivity in the simplest terms, suitable either as introductions or as summaries for examination preparation. These chapters are augmented by detailed, systematic discussions of the chemical reactivity of particular heterocyclic systems. References to both primary literature and reviews are given throughout the text, and whilst these are essential for postgraduate teaching and to research workers, they do not interfere with the readability of the text for undergraduate students.
A textbook for a course for students in the second or third year of undergraduate chemistry study, but more advanced material suitable for graduates is also included. Joule (chemistry, U. of Manchester) and Mills, a scientist in the private sector, introduce the fundamentals of hetercyclic reactivity and synthesis. They provide answers to the exercises. The fourth edition incorporates new findings; the earlier ones appeared between 1972 and 1995. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Preface | ||
Definitions of abbreviations | ||
1 | Structures and main physical properties of aromatic heterocycles | 1 |
2 | Reactivity of aromatic heterocycles | 18 |
3 | Synthesis of aromatic heterocycles | 56 |
4 | Typical reactivity of pyridines, quinolines and isoquinolines | 64 |
5 | Pyridines: reactions and synthesis | 72 |
6 | Quinolines and isoquinolines: reactions and synthesis | 120 |
7 | Typical reactivity of pyrylium and benzopyrylium ions, pyrones and benzopyrones | 146 |
8 | Pyryliums, 2- and 4-pyrones: reactions and synthesis | 148 |
9 | Benzopyryliums and benzopyrones: reactions and synthesis | 166 |
10 | Typical reactivity of the diazines: pyridazine, pyrimidine and pyrazine | 185 |
11 | The diazines: pyridazine, pyrimidine and pyrazine: reactions and synthesis | 189 |
12 | Typical reactivity of pyrroles, thiophenes and furans | 225 |
13 | Pyrroles: reactions and synthesis | 229 |
14 | Thiophenes: reactions and synthesis | 259 |
15 | Furans: reactions and synthesis | 278 |
16 | Reactivity of indoles, benzo[b]thiophenes, benzo[b]furans, isoindoles, benzo[c]thiophenes and isobenzofurans | 301 |
17 | Indoles: reactions and synthesis | 305 |
18 | Benzo[b]thiophenes and benzo[b]furans: reactions and synthesis | 350 |
19 | Isoindoles, benzo[c]thiophenes and isobenzofurans: reactions and synthesis | 360 |
20 | Typical reactivity of 1,3- and 1,2-azoles | 367 |
21 | 1,3-Azoles: imidazoles, thiazoles and oxazoles: reactions and synthesis | 370 |
22 | 1,2-Azoles: pyrazoles, isothiazoles and isoxazoles: reactions and synthesis | 394 |
23 | Purines: reactions and synthesis | 409 |
24 | Heterocycles containing a ring-junction nitrogen | 434 |
25 | Heterocycles containing more than two hetero atoms | 447 |
26 | Saturated and partially unsaturated heterocyclic compounds: reactions and synthesis | 463 |
27 | Appendix: answers to exercises | 479 |
Index | 485 |