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Heterocyclic Chemistry »

Book cover image of Heterocyclic Chemistry by John A. Joule

Authors: John A. Joule, Keith Mills
ISBN-13: 9781405193658, ISBN-10: 1405193654
Format: Hardcover
Publisher: Wiley, John & Sons, Incorporated
Date Published: June 2010
Edition: (Non-applicable)

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Author Biography: John A. Joule

John Joule is Emeritus Professor in the School of Chemistry, The University of Manchester, UK

Keith Mills spent 25 years in the Medicinal Chemistry and Development Chemistry departments at GlaxoSmithKline, Stevenage, UK, and is now an independent consultant.

Book Synopsis

Heterocyclic chemistry is a central part of organic chemistry and biochemistry. The term refers to a particular set of chemical structure characteristics, with many drugs and specialty chemicals, and most agrochemicals, containing these characteristics. Heterocyclic Chemistry by Joule & Mills has established itself as the premier textbook of heterocyclic chemistry, used by high level undergraduates, postgraduates and industrial researchers all over the world.

Heterocyclic Chemistry covers the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. It also includes more advanced material, making the book appropriate for postgraduate taught courses and to researchers, either at postgraduate degree level or those working with heterocyclic compounds in industry. Essential teaching material is collected in specific introductory chapters, explaining the principles of heterocyclic reactivity in the simplest terms, suitable either as introductions or as summaries for examination preparation. These chapters are augmented by detailed, systematic discussions of the chemical reactivity of particular heterocyclic systems. References to both primary literature and reviews are given throughout the text, and whilst these are essential for postgraduate teaching and to research workers, they do not interfere with the readability of the text for undergraduate students.

Booknews

A textbook for a course for students in the second or third year of undergraduate chemistry study, but more advanced material suitable for graduates is also included. Joule (chemistry, U. of Manchester) and Mills, a scientist in the private sector, introduce the fundamentals of hetercyclic reactivity and synthesis. They provide answers to the exercises. The fourth edition incorporates new findings; the earlier ones appeared between 1972 and 1995. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Table of Contents

Preface
Definitions of abbreviations
1Structures and main physical properties of aromatic heterocycles1
2Reactivity of aromatic heterocycles18
3Synthesis of aromatic heterocycles56
4Typical reactivity of pyridines, quinolines and isoquinolines64
5Pyridines: reactions and synthesis72
6Quinolines and isoquinolines: reactions and synthesis120
7Typical reactivity of pyrylium and benzopyrylium ions, pyrones and benzopyrones146
8Pyryliums, 2- and 4-pyrones: reactions and synthesis148
9Benzopyryliums and benzopyrones: reactions and synthesis166
10Typical reactivity of the diazines: pyridazine, pyrimidine and pyrazine185
11The diazines: pyridazine, pyrimidine and pyrazine: reactions and synthesis189
12Typical reactivity of pyrroles, thiophenes and furans225
13Pyrroles: reactions and synthesis229
14Thiophenes: reactions and synthesis259
15Furans: reactions and synthesis278
16Reactivity of indoles, benzo[b]thiophenes, benzo[b]furans, isoindoles, benzo[c]thiophenes and isobenzofurans301
17Indoles: reactions and synthesis305
18Benzo[b]thiophenes and benzo[b]furans: reactions and synthesis350
19Isoindoles, benzo[c]thiophenes and isobenzofurans: reactions and synthesis360
20Typical reactivity of 1,3- and 1,2-azoles367
211,3-Azoles: imidazoles, thiazoles and oxazoles: reactions and synthesis370
221,2-Azoles: pyrazoles, isothiazoles and isoxazoles: reactions and synthesis394
23Purines: reactions and synthesis409
24Heterocycles containing a ring-junction nitrogen434
25Heterocycles containing more than two hetero atoms447
26Saturated and partially unsaturated heterocyclic compounds: reactions and synthesis463
27Appendix: answers to exercises479
Index485

Subjects