Contents
ContributorsPrefacePART 1: Introduction to Clinical Medicine1 The Practice of Medicine
The Editors2 Global Issues in Medicine
Jim Yong Kim / Paul Farmer3 Decision-Making in Clinical Medicine
Daniel B. Mark4 Screening and Prevention of Diseases
Gary J. Martin5 Principles of Clinical Pharmacology
Dan M. Roden6 Women’s Health
Andrea Dunaif7 Medical Disorders during Pregnancy
Robert L. Barbieri / John T. Repke8 Medical Evaluation of the Surgical Patient
Wei C. Lau / Kim A. Eagle 9 Geriatric Medicine
Lisa B. Caruso / Rebecca A. Silliman10 Complementary and Alternative Medicine
Stephen E. Straus11 Palliative and End-of-Life Care
Ezekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel e1 The Safety and Quality of Health Care
David W. Batese2 Economic Considerations in the Practice of Medicine
David Meltzere3 Racial and Ethnic Disparities in Health Care
Joseph R. Betancourt / David Blumenthale4 Ethical Issues in Clinical Medicine
Bernard LoPART 2: Cardinal Manifestations and Presentation of DiseasesSection 1: Pain12 Pain: Pathophysiology and Management
Howard L. Fields / Joseph B. Martin13 Chest Discomfort
Thomas H. Lee14 Abdominal Pain
William Silen15 Headache
Peter J. Goadsby / Neil H. Raskin16 Back and Neck Pain
John W. EngstromSection 2: Alterations in Body Temperature17 Fever and Hyperthermia
Charles A. Dinarello / Reuven Porat18 Fever and Rash
Elaine T. Kaye / Kenneth M. Kayee5 Atlas of Rashes Associated with Fever
Kenneth M. Kaye / Elaine T. Kaye 19 Fever of Unknown Origin
Jeffery A. Gelfand / Michael V. Callahan20 Hypothermia and Frostbite
Daniel F. DanzlSection 3: Nervous System Dysfunction21 Syncope
Mark D. Carlson22 Dizziness and Vertigo
Robert B. Daroff23 Weakness and Paralysis
Michael J. Aminoff24 Gait and Balance Disorders
Lewis Sudarsky25 Numbness, Tingling, and Sensory Loss
Michael J. Aminoff / Arthur K. Asbury26 Confusion and Delirium
S. Andrew Josephson / Bruce L. Millere6 Memory Loss
Thomas D. Bird / Bruce L. Miller27 Aphasia, Memory Loss, and Other Focal Cerebral Disorders
M.-Marsel Mesulam28 Sleep Disorders
Charles A. Czeisler / John W. Winkelman / Gary S. RichardsonSection 4: Disorders of Eyes, Ears, Nose, and Throat29 Disorders of the Eye
Jonathan C. Horton30 Disorders of Smell, Taste, and Hearing
Anil K. Lalwani31 Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Tract Infections
Michael A. Rubin / Ralph Gonzales / Merle A. Sande32 Oral Manifestations of Disease
Samuel C. Dursoe7 Atlas of Oral Manifestations of Disease
Samuel C. Durso / Janet A. Yellowitz / Jane C. AtkinsonSection 5: Alterations in Circulatory and Respiratory Functions 33 Dyspnea and Pulmonary Edema
Richard M. Schwartzstein34 Cough and Hemoptysis
Steven E. Weinberger / David A. Lipson35 Hypoxia and Cyanosis
Eugene Braunwald36 Edema
Eugene Braunwald / Joseph Loscalzoe8 Approach to the Patient with a Heart Murmur
Patrick T. O’Gara / Eugene Braunwald37 Palpitations
Joseph LoscalzoSection 6: Alterations in Gastrointestinal Function38 Dysphagia
Raj K. Goyal39 Nausea, Vomiting, and Indigestion
William L. Hasler40 Diarrhea and Constipation
Michael Camilleri / Joseph A. Murray41 Weight Loss
Carol M. Reife42 Gastrointestinal Bleeding
Loren Laine43 Jaundice
Daniel S. Pratt / Marshall M. Kaplan44 Abdominal Swelling and Ascites
Robert M. Glickman / Roshini RajapaksaSection 7: Alterations in Renal and Urinary Tract Function45 Azotemia and Urinary Abnormalities
Bradley M. Denker / Barry M. Brenner e9 Atlas of Urinary Sediments and Renal Biopsies
Agnes B. Fogo / Eric G. Neilsen 46 Fluid and Electrolyte Disturbances
Gary G. Singer / Barry M. Brenner47 Hypercalcemia and Hypocalcemia
Sundeep Khosla48 Acidosis and Alkalosis
Thomas B. DuBose, Jr.Section 8: Alterations in Sexual Function and Reproduction49 Sexual Dysfunction
Kevin T. McVary50 Hirsutism and Virilization
David A. Ehrmann51 Menstrual Disorders and Pelvic Pain
Janet E. HallSection 9: Alterations in the Skin52 Approach to the Patient with a Skin Disorder
Thomas J. Lawley / Kim B. Yancey53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
Calvin O. McCall / Thomas J. Lawley54 Skin Manifestations of Internal Disease
Jean L. Bolognia / Irwin M. Braverman55 Immunologically Mediated Skin Diseases
Kim B. Yancey / Thomas J. Lawley56 Cutaneous Drug Reactions
Jean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub 57 Photosensitivity and Other Reactions to Light
David R. Bickers e10 Atlas of Skin Manifestations of Internal Disease
Thomas J. Lawley / Stephen TempletonSection 10: Hematologic Alterations 58 Anemia and Polycythemia
John W. Adamson / Dan L. Longo59 Bleeding and Thrombosis
Barbara A. Konkle60 Enlargement of Lymph Nodes and Spleen
Patrick H. Henry / Dan L. Longo61 Disorders of Granulocytes and Monocytes
Steven M. Holland /John I. Galline11 Atlas of Hematology and Analysis of Peripheral Blood Smears
Dan L. LongoPART 3: Genetics and Disease62 Principles of Human Genetics
J. Larry Jameson / Peter Kopp63 Chromosome Disorders
Terry J. Hassold / Stuart Schwartz64 The Practice of Genetics in Clinical Medicine
Susan Miesfeldt / J. Larry Jameson65 Gene Therapy in Clinical Medicine
Katherine A. High PART 4: Regenerative Medicine66 Stem Cell Biology
Minoru S. H. Ko67 Applications of Stem Cell Biology in Clinical Medicine
Jack A. Kessler68 Hematopoietic Stem Cells
David T. Scadden / Dan L. Longo69 Tissue Engineering
Jennifer Anderson /Joseph P. Vacanti PART 5: Nutrition70 Nutritional Requirements and Dietary Assessment
Johanna Dwyer71 Vitamin and Trace Mineral Deficiency and Excess
Robert M. Russell / Paolo M. Suter72 Malnutrition and Nutritional Assessment
Douglas C. Heimburger73 Enteral and Parenteral Nutrition Therapy
Bruce R. Bistrian / David F. Driscoll74 Biology of Obesity
Jeffrey S. Flier / Eleftheria Maratos-Flier75 Evaluation and Management of Obesity
Robert F. Kushner76 Eating Disorders
B. Timothy WalshPART 6: Oncology and HematologySection 1: Neoplastic Disorders77 Approach to the Patient with Cancer
Dan L. Longo78 Prevention and Early Detection of Cancer
Otis W. Brawley / Barnett S. Kramer79 Cancer Genetics
Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein80 Cancer Cell Biology and Angiogenesis
Robert G. Fenton / Dan L. Longo81 Principles of Cancer Treatment
Edward A. Sausville / Dan L. Longo82 Infections in Patients with Cancer
Robert Finberg83 Cancer of the Skin
Arthur J. Sober / Hensin Tsao / Carl V. Washington84 Head and Neck Cancer
Everett E. Vokes85 Neoplasms of the Lung
John D. Minna / Joan H. Schiller86 Breast Cancer
Marc E. Lippman87 Gastrointestinal Tract Center
Robert J. Mayer88 Tumors of the Liver and Biliary Tree
Brian I. Carr89 Pancreatic Cancer
Yu Jo Chua / David Cunningham 90 Bladder and Renal Cell Carcinomas
Howard I. Scher / Robert J. Motzer91 Benign and Malignant Diseases of the Prostate
Howard I. Scher92 Testicular Cancer
Robert J. Motzer / George J. Bosl93 Gynecologic Malignancies
Robert C. Young94 Soft Tissue and Bone Sarcomas and Bone Metastases
Shreyaskumar R. Patel / Robert S. Benjamin95 Carcinoma of Unknown Primary
Gauri R. Varadhachary /James L. Abbruzzese96 Paraneoplastic Syndromes: Endocrinologic/Hematologic
J. Larry Jameson / Bruce E. Johnson97 Paraneoplastic Neurologic Syndromes
Josep Dalmau / Myrna R. Rosenfelde12 Thymoma
Dan L. Longoe13 Late Consequences of Cancer and Its Treatment
Michael C. Perry / Dan L. LongoSection 2: Hematopoietic Disorders98 Iron Deficiency and Other Hypoproliferative Anemias
John W. Adamson99 Disorders of Hemoglobin
Edward J. Benz, Jr.100 Megaloblastic Anemias
A. Victor Hoffbrand101 Hemolytic Anemias and Anemia Due to Acute Blood Loss
Lucio Luzzatto102 Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes
Neal S. Young103 Polycythemia Vera and Other Myeloproliferative Diseases
Jerry L. Spivak104 Acute and Chronic Myeloid Leukemia
Meir Wetzler /John C. Byrd / Clara D. Bloomfield105 Malignancies of Lymphoid Cells
Dan L. Longo106 Plasma Cell Disorders
Nikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson107 Transfusion Biology and Therapy
Jeffery S. Dzieczkowski / Kenneth C. Anderson108 Hematopoietic Cell Transplantation
Frederick R. ApplebaumSection 3: Disorders of Hemostasis109 Disorders of Platelets and Vessel Wall
Barbara A. Konkle110 Coagulation Disorders
Valder Arruda / Katherine A. High 111 Venous Thrombosis
F.R. Rosendaal / H.R. Büller112 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
Jeffery I. WeitzPART 7: Infectious DiseasesSection 1: Basic Considerations in Infectious Diseases113 Introduction to Infectious Diseases: Host-Pathogen Interactions
Lawrence C. Madoff / Dennis L. Kasper114 Molecular Mechanisms of Microbial Pathogenesis
Gerald B. Pier115 Approach to the Acutely Ill Infected Febrile Patient
Tamar F. Barlam / Dennis L. Kasper116 Immunization Principles and Vaccine Use
Gerald T. Keusch / Kenneth J. Bart / Mark Miller117 Health Advice for International Travel
J.S. Keystone / Phyllis E. Kozarskye14 Laboratory Diagnosis of Infectious Diseases
Alexander J. McAdam / Andrew B. OnderdonkSection 2: Clinical Syndromes: Community-Acquired Infections118 Infective Endocarditis
Adolf W. Karchmer119 Infections of the Skin, Muscle, and Soft Tissues
Dennis L. Stevens120 Osteomyelitis
Jeffrey Parsonnet121 Intraabdominal Infections and Abscesses
Miriam J. Baron / Dennis L. Kasper 122 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
Joan R. Butterton / Stephen B. Calderwood 123 Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis
Dale N. Gerding / Stuart Johnson124 Sexually Transmitted Infections: Overview and Clinical Approach
King K. Holmese15 Infectious Complications of Burns and Bites
Lawrence C. Madoff / Florencia PereyraSection 3: Clinical Syndromes: Health Care-Associated Infections125 Health Care-Associated Infections
Robert A. Weinstein126 Infections in Transplant Recipients
Robert Finberg /Joyce FingerothSection 4: Approach to Therapy for Bacterial Diseases127 Treatment and Prophylaxis of Bacterial Infections
Gordon L. Archer / Ronald E. PolkSection 5: Diseases Caused by Gram-Positive Bacteria128 Pneumococcal Infections
Daniel M. Musher129 Staphylococcal Infections
Franklin D. Lowy130 Streptococcal and Enterococcal Infections
Michael R. Wessels131 Diphtheria and Other Infections Caused by Corynebacteria and Related Species
William R. Bishai / John R. Murphy 132 Infections Caused by Listeria monocytogenes
Elizabeth L. Hohmann / Daniel A. Portnoy133 Tetanus
Elias Abrutyn134 Botulism
Elias Abrutyn135 Gas Gangrene and Other Clostridial Infections
Dennis L. Kasper /Lawrence C. MadoffSection 6: Diseases Caused by Gram-Negative Bacteria136 Meningococcal Infections
Lee M. Wetzler137 Gonococcal Infections
Sanjay Ram / Peter A. Rice138 Moraxella Infections
Daniel M. Musher139 Haemophilus Infections
Timothy F. Murphy140 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
Tamar F. Barlam / Dennis L. Kasper 141 Legionella Infection
Miguel Sabria / Victor L. Yu142 Pertussis and Other Bordetella Infections
Scott A. Halperin143 Diseases Caused by Gram-Negative Enteric Bacilli
Thomas A. Russo / James R. Johnson144 Helicobacter pylori Infections
John C. Atherton / Martin J. Blaser145 Infections Due to Pseudomonas Species and Related Organisms
Reuben Ramphal146 Salmonellosis
David A. Pegues / Samuel I. Miller147 Shigellosis
Philippe Sansonetti / Jean Bergounioux148 Infections Due to Campylobacter and Related Species
Martin J. Blaser149 Cholera and Other Vibrioses
Matthew K. Waldor / Gerald T. Keusch150 Brucellosis
Michael J. Corbel / Nicholas J. Beeching151 Tularemia
Richard F. Jacobs / Gordon E. Schutze152 Plague and Other Yersinia Infections
David T. Dennis / Grant L. Campbell153 Bartonella Infections, Including Cat-Scratch Disease
David H. Spach / Emily Darby154 Donovanosis
Gavin HartSection 7: Miscellaneous Bacterial Infections155 Nocardiosis
Gregory A. Filice156 Actinomycosis
Thomas A. Russo157 Infections Due to Mixed Anaerobic Organisms
Dennis L. Kasper / Ronit Cohen-PoradosuSection 8: Mycobacterial Diseases158 Tuberculosis
Mario C. Raviglione / Richard J. O’Brien159 Leprosy (Hansen’s Disease)
Robert H. Gelber160 Nontuberculous Mycobacteria
C. Fordham von Reyn161 Antimycobacterial Agents
Richard J. Wallace, Jr. / David E. GriffithSection 9: Spirochetal Disease162 Syphilis
Sheila A. Lukehart163 Endemic Treponematoses
Sheila A. Lukehart164 Leptospirosis
Peter Speelman / Rudy Harkskeerl165 Relapsing Fever
David T. Dennis166 Lyme Borreliosis
Allen C. SteereSection 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae167 Rickettsial Diseases
David H. Walker / J. Stephen Dumler / Thomas Marrie168 Infections Due to Mycoplasmas
William M. McCormack169 Chlamydial Infections
Walter E. StammSection 11: Viral Diseases: General Considerations170 Medical Virology
Fred Wang /Elliott Kieff171 Antiviral Chemotherapy, Excluding Antiretroviral Drugs
Lindsey R. Baden / Raphael DolinSection 12: Infections Due to DNA Viruses172 Herpes Simplex Viruses
Lawrence Corey73 Varicella-Zoster Virus Infections
Richard J. Whitley174 Epstein-Barr Virus Infections, Including Infectious Mononucleosis
Jeffry I. Cohen175 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
Martin S. Hirsch176 Molluscum Contagiosum, Monkeypox, and Other Poxviruses, Excluding Smallpox Virus
Fred Wang177 Parvovirus Infections
Kevin E. Brown178 Human Papillomavirus Infections
Richard C. ReichmanSection 13: Infections Due to DNA and RNA Respiratory Viruses179 Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)
Raphael Dolin180 Influenza
Raphael DolinSection 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses181 The Human Retroviruses
Dan L. Longo /Anthony S. Fauci182 Human Immunodeficiency Virus Disease: AIDS and Related Disorders
Anthony S. Fauci / H. Clifford Lane Section 15: Infections Due to RNA Viruses183 Viral Gastroenteritis
Umesh D. Parashar / Roger I. Glass184 Enteroviruses and Reoviruses
Jeffery I. Cohen185 Measles (Rubeola)
Anne Gershon186 Rubella (German Measles)
Anne Gershon187 Mumps
Anne Gershon188 Rabies and Other Rhabdovirus Infections
Alan C. Jackson / Eric C. Johannsen189 Infections Caused by Arthropod- and Rodent-Borne Viruses
Clarence J. Peters190 Ebola and Marburg Viruses
Clarence J. PetersSection 16: Fungal and Algal Infections191 Diagnosis and Treatment of Fungal Infections
John E. Edwards, Jr.192 Histoplasmosis
Chadi A. Hage / L. Joseph Wheat 193 Coccidioidomycosis
Neil M. Ampel194 Blastomycosis
Stanley W. Chapman / Donna C. Sullivan195 Cryptococcosis
Arturo Casadevall196 Candidiasis
John E. Edwards, Jr.197 Aspergillosis
David W. Denning198 Mucormycosis
Alan M. Sugar199 Miscellaneous Mycoses and Algal Infections
Stanley W. Chapman / Donna C. Sullivan200 Pneumocystis Infection
A. Geroge Smulian /Peter D. WalzerSection 17: Protozoal and Helminthic Infections: General Considerationse16 Laboratory Diagnosis of Parasitic Infections
Sharon L. Reed / Charles E. Davis201 Agents Used to Treat Parasitic Infections
Thomas A. Mooree17 Pharmacology of Agents Used to Treat Parasitic Infections
Thomas A. MooreSection 18: Protozoal Infections202 Amebiasis and Infection with Free-Living Amebas
Sharon L. Reed203 Malaria
Nicholas J. White / Joel G. Breman204 Babesiosis
Jeffry Gelfand / Edouard Vanniere18 Atlas of Blood Smears of Malaria and Babesiosis
Nicholas J. White / Joel G. Breman205 Leishmaniasis
Barbara L. Herwaldt206 Trypanosomiasis
Louis V. Kirchhoff207 Toxoplasma Infections
Lloyd H. Kasper208 Protozoal Intestinal Infections and Trichomoniasis
Peter F. WellerSection 19: Helminthic Infections209 Trichinella and Other Tissue Nematodes
Peter F. Weller210 Intestinal Nematodes
Peter F. Weller /Thomas B. Nutman211 Filarial and Related Infections
Thomas B. Nutman / Peter F. Weller212 Schistosomiasis and Other Trematode Infections
Adel A.F. Mahmoud213 Cestodes
A. Clinton White, Jr. / Peter F. Weller PART 8: Bioterrorism and Clinical Medicine214 Microbial Bioterrorism
H. Clifford Lane / Anthony S. Fauci215 Chemical Bioterrorism
Charles G. Hurst / Jonathan Newmark / James A. Romano, Jr.216 Radiation Bioterrorism
Zelig A. Tochner / Eli GlatsteinPART 9: Disorders of the Cardiovascular SystemSection 1: Introduction to Cardiovascular Disorders217 Basic Biology of the Cardiovascular System
Joseph Loscalzo / Peter Libby / Eugene Braunwald 218 Epidemiology of Cardiovascular Disease
Thomas A. Gaziano / J. Michael Gaziano 219 Approach to the Patient with Possible Cardiovascular Disease
Eugene BraunwaldSection 2: Diagnosis of Cardiovascular Disorders220 Physical Examination of the Cardiovascular System
Robert A. O’Rourke /Eugene Braunwald221 Electrocardiography
Ary L. Goldbergere19 Atlas of Electrocardiography
Ary L. Goldberger222 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging
Rick A. Nishimura / Raymond J. Gibbons / James F. Glockner /A. Jamil Tajike20 Atlas of Noninvasive Cardiac Imaging
Rick A. Nishimura / Raymond J. Gibbons / James F. Glockner / A. Jamil Tajik223 Diagnostic Cardiac Catheterization and Angiography
Donald S. BaimSection 3: Disorders of Rhythm224 Principles of Electrophysiology
Gordon F. Tomaselli225 The Bradyarrhythmias
Gordon F. Tomaselli226 The Tachyarrhythmias
Francis Marchlinksie21 Atlas of Cardiac Arrhythmias
Ary L. GoldbergerSection 4: Disorders of the Heart227 Heart Failure and Cor Pulmonale
Douglas L. Mann228 Cardiac Transplantation and Prolonged Assisted Circulation
Sharon A. Hunt229 Congenital Heart Disease in the Adult
John S. Child230 Valvular Heart Disease
Patrick O’Gara / Eugene Braunwald 231 Cardiomyopathy and Myocarditis
Joshua Wynne / Eugene Braunwald232 Pericardial Disease
Eugene Braunwald233 Tumors and Trauma of the Heart
Eric H. Awtry / Wilson S. Colucci234 Cardiac Manifestations of Systemic Disease
Eric H. Awtry / Wilson S. ColucciSection 5: Vascular Disease235 The Pathogenesis, Prevention, and Treatment of Atherosclerosis
Peter Libbye22 Atlas of Atherosclerosis
Peter Libby236 The Metabolic Syndrome
Robert H. Eckel237 Ischemic Heart Disease
Elliott M. Antman / Andrew P. Selwyn/ Eugene Braunwald / Joseph Loscalzo238 Unstable Angina and Non-ST-Elevation Myocardial Infarction
Christopher P. Cannon / Eugene Braunwald239 ST-Segment Elevation Myocardial Infarction
Elliott M. Antman / Eugene Braunwald240 Percutaneous Coronary Intervention
Donald S. Baime23 Atlas of Percutaneous Revascularization
Donald S. Baim241 Hypertensive Vascular Disease
Ted A. Kotchen242 Diseases of the Aorta
Mark A. Creager / Joseph Loscalzo243 Vascular Diseases of the Extremities
Mark A. Creager / Joseph Loscalzo244 Pulmonary Hypertension
Stuart RichPART 10: Disorders of the Respiratory SystemSection 1: Diagnosis of Respiratory Disorders245 Approach to the Patient with Disease of the Respiratory System
David A. Lipson / Steven E. Weinberger246 Disturbances of Respiratory Function
Steven E. Weinberger /Ilene M. Rosen247 Diagnostic Procedures in Respiratory Diseases
Scott Manaker / Steven E. Weinbergere24 Atlas of Chest Imaging
Patricia A. Kritek / John J. Reilly, Jr. Section 2: Diseases of the Respiratory System248 Asthma
Peter J. Barnes249 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
Joel N. Kline / Gary W. Hunninghake250 Environmental Lung Disease
Frank E. Speizer / John R. Balmes 251 Pneumonia
Lionel A. Mandell / Richard Wunderink252 Bronchiectasis and Lung Abscess
Gregory Tino / Steven E. Weinberger253 Cystic Fibrosis
Richard C. Boucher254 Chronic Obstructive Pulmonary Disease
John J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro255 Interstitial Lung Diseases
Talmadge E. King, Jr.256 Deep Venous Thrombosis and Pulmonary Thromboembolism
Samuel Z. Goldhaber257 Disorders of the Pleura and Mediastinum
Richard W. Light258 Disorders of Ventilation
Eliot A. Phillipson 259 Sleep Apnea
Neil J. Douglas260 Lung Transplantation
Elbert P. TrulockPART 11: Critical Care MedicineSection 1: Respiratory Critical Care261 Principles of Critical Care Medicine
John P. Kress / Jesse B. Hall262 Acute Respiratory Distress Syndrome
Bruce D. Levy / Steve D. Shapiro263 Mechanical Ventilatory Support
Edward P. IngenitoSection 2: Shock and Cardiac Arrest264 Approach to the Patient with Shock
Ronald V. Maier 265 Severe Sepsis and Septic Shock
Robert S. Munford266 Cardiogenic Shock and Pulmonary Edema
Judith S. Hochman / David H. Ingbar267 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
Robert J. Myerberg / Agustin CastellanosSection 3: Neurologic Critical Care268 Coma
Allan H. Ropper269 Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage
J. Claude Hemphill, III / Wade S. SmithSection 4: Oncologic Emergencies270 Oncologic Emergencies
Rasim Gucalp / Janice P. DutcherPART 12: Disorders of the Kidney and Urinary Tract271 Cellular and Molecular Biology of the Kidney
Alfred L. George, Jr. / Eric G. Neilson272 Adaptation of the Kidney to Renal Injury
Raymond C. Harris / Eric G. Neilson273 Acute Renal Failure
Kathleen D. Liu / Glenn M. Chertow 274 Chronic Kidney Disease
Joanne M. Bargman / Karl Skorecki 275 Dialysis in the Treatment of Renal Failure
Kathleen D. Liu / Glenn M. Chertow 276 Transplantation in the Treatment of Renal Failure
Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh277 Glomerular Diseases
Julia B. Lewis / Eric G. Neilson278 Polycystic Kidney Disease and Other Inherited Tubular Disorders
David J. Salant / Parul S. Patel279 Tubulointerstitial Diseases of the Kidney
Alan S. L. Yu / Barry M. Brenner280 Vascular Injury to the Kidney
Kamal F. Badr / Barry M. Brenner281 Nephrolithiasis
John R. Asplin / Fredric L. Coe / Murray J. Favus282 Urinary Tract Infections, Pyelonephritis, and Prostatitis
Walter E. Stamm283 Urinary Tract Obstruction
Julian L. Seifter / Barry M. BrennerPART 13: Disorders of the Gastrointestinal SystemSection 1: Disorders of the Alimentary Tract284 Approach to the Patient with Gastrointestinal Disease
William L. Hasler / Chung Owyang285 Gastrointestinal Endoscopy
Louis Michel Wong-Kee-Song / Mark Topaziane25 Video Atlas of Gastrointestinal Endoscopy
Louis Michel Wong-Kee-Song / Mark Topazian286 Diseases of the Esophagus
Raj. K. Goyal287 Peptic Ulcer Disease and Related Disorders
John Del Valle288 Disorders of Absorption
Henry J. Binder289 Inflammatory Bowel Disease
Sonia Friedman / Richard S. Blumberg290 Irritable Bowel Syndrome
Chung Owyang291 Diverticular Disease and Common Anorectal Disorders
Susan L. Gearhart292 Mesenteric Vascular Insufficiency
Susan L. Gearhart293 Acute Intestinal Obstruction
Susan L. Gearhart / William Silen294 Acute Appendicitis and Peritonitis
Susan L. Gearhart / William SilenSection 2: Liver and Biliary Tract Disease295 Approach to the Patient with Liver Disease
Marc Ghany /Jay H. Hoofnagle296 Evaluation of Liver Function
Daniel S. Pratt / Marshall M. Kaplan297 The Hyperbilirubinemias
Allan W. Wolkoff298 Acute Viral Hepatitis
Jules L. Dienstag299 Toxic and Drug-Induced Hepatitis
Jules L. Dienstag300 Chronic Hepatitis
Jules L. Dienstag301 Alcoholic Liver Disease
Mark E. Mailliard / Michael F. Sorrell302 Cirrhosis and Its Complications
Bruce R. Bacone26 Atlas of Liver Biopsies
Jules L. Dienstag / Atul K. Bhan303 Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver
Bruce R. Bacon304 Liver Transplantation
Jules L. Dienstag /Raymond T. Chung305 Diseases of the Gallbladder and Bile Ducts
Norton J. Greenberger / Gustav PaumgartnerSection 3: Disorders of the Pancreas306 Approach to the Patient with Pancreatic Disease
Phillip P. Toskes / Norton J. Greenberger307 Acute and Chronic Pancreatitis
Norton J. Greenberger / Phillip P. Toskes PART 14: Disorders of the Immune System, Connective Tissue, and JointsSection 1: The Immune System in Health and Disease308 Introduction to the Immune System
Barton F. Haynes / Kelly A. Soderberg / Anthony S. Fauci309 The Major Histocompatability Complex
Gerald T. Nepom310 Primary Immune Deficiency Diseases
Max D. Cooper / Harry W. Schroeder, Jr.e27 Primary Immunodeficiencies Associated with or Secondary to Other Diseases
Max D. Cooper / Harry W. Schroeder, Jr.Section 2: Disorders of Immune-Mediated Injury311 Allergies, Anaphylaxis, and Systemic Mastocytosis
K. Frank Austen312 Autoimmunity and Autoimmune Diseases
Peter E. Lipsky / Betty Diamond313 Systemic Lupus Erythematosus
Bevra Hannahs Hahn314 Rheumatoid Arthritis
Peter E. Lipsky315 Acute Rheumatoid Fever
Jonathan R. Carapetis316 Systemic Sclerosis (Scleroderma) and Related Disorders
John Varga317 Sjögren’s Syndrome
Haralampos M. Moutsopoulos318 The Spondyloarthritides
Joel D. Taurog319 The Vasculitis Syndromes
Carol A. Langford / Anthony S. Faucie28 Atlas of Clinical Imaging of the Vasculitic Diseases
Carol A. Langford / Anthony S. Fauci320 Behçet’s Syndrome
Haralampos M. Moutsopoulos321 Relapsing Polychondritis
Carol A. Langford /Bruce C. Gilliland322 Sarcoidosis
Robert P. Baughman /Elyse E. Lower323 Familial Mediterranean Fever
Daniel L. Kastner324 Amyloidosis
David C. Seldin / Martha Skinner Section 3: Disorders of the Joints and Adjacent Tissues325 Approach to Articular and Musculoskeletal Disorders
John J. Cush / Peter E. Lipsky326 Osteoarthritis
David T. Felson327 Gout and Other Crystal Arthropathies
H. Ralph Schumacher / Lan X. Chen328 Infectious Arthritis
Lawrence C. Madoff329 Fibromyalgia
Carol A. Langford /Bruce C. Gilliland330 Arthritis Associated with Systemic Disease and Other Arthritides
Carol A. Langford / Bruce C. Gilliland331 Periarticular Disorders of the Extremities
Carol A. Langford / Bruce C. GillilandPART 15: Endocrinology and MetabolismSection 1: Endocrinology332 Principles of Endocrinology
J. Larry Jameson333 Disorders of the Anterior Pituitary and Hypothalamus
Shlomo Melmed / J. Larry Jameson334 Disorders of the Neurohypophysis
Gary L. Robertson335 Disorders of the Thyroid Gland
J. Larry Jameson / Anthony P. Weetman336 Disorders of the Adrenal Cortex
Gordon H. Williams / Robert G. Dluhy337 Pheochromocytoma
Hartmut P.H. Neumann33