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Goodman & Gilman's The Pharmacological Basis of Therapeutics, Eleventh Edition » (11st Edition)

Book cover image of Goodman & Gilman's The Pharmacological Basis of Therapeutics, Eleventh Edition by Laurence Brunton

Authors: Laurence Brunton
ISBN-13: 9780071422802, ISBN-10: 0071422803
Format: Hardcover
Publisher: McGraw-Hill Companies, The
Date Published: August 2005
Edition: 11st Edition

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Author Biography: Laurence Brunton

Laurence L. Brunton, PhD

Professor of Pharmacology and Medicine

University of California, San Diego

Laurence Brunton trained under Alfred Goodman-Gilman and is nationally recognized for his expertise in cell signaling and cardivacular pharmacology. He has published more than 200 original research papers.

John S. Lazo, PhD

Professor and Chairman

Department of Pharmacology

University of Pittsburgh School of Medicine

Under John Lazo's leadership as Chairman, the Department of Pharmacology is regarded as one of the leading academic programs in the United States. He has published extensively in the field of cancer pharmacology.

Keith Parker, MD, PhD

Professor of Internal Medicine and Pharmacology

Division of Endocrinology

Department of Internal Medicine

University of Texas Southwestern School of Medicine

Book Synopsis

Comprehensive drug reference for students and practitioners. Includes abundant references, illustrations, and a fold-out section on the autonomic nervous system.

Doody Review Services

Reviewer:Thomas L. Pazdernik, PhD(University of Kansas Medical Center)
Description:The 11th edition of Goodman & Gilman continues to be the most comprehensive and authoritative single source on the pharmacology of drugs. The first edition was published by Alfred Gilman and Louis Goodman in 1941. It soon became known as the bible of pharmacology and, even though editorship and chapter authorships have changed continuously from edition to edition, this remains the gold standard of pharmacology textbooks.
Purpose:The editors have done a remarkable job of condensing information from a rapidly expanding field to slightly reduce the number of pages from the previous edition while adhering to the principles of the original authors and retaining the completeness for which the book is known. The editors have standardized the organization to provide readers with essential physiology and basic pharmacology while providing the kinds of details a physician needs to know under easily identifiable headings. The editors have done a marvelous job in achieving the high standards expected by readers.
Audience:Although this publication may be too extensive for most students to read cover to cover while taking a pharmacology course, it should be a required resource for all who study, research, teach, or practice any facet of healthcare involving the use of medications.
Features:The 11th edition continues to provide the most comprehensive, current, and authoritative information on drugs. This latest version has new chapters on drug transporters, drug metabolism, and pharmacogenetics. The print version comes with a non-transferable subscription to an online digital version. Each drug in the digital version is hyperlinked to Gold Standards, Clinical Pharmacology Online, an online database. PDA downloads are available. In my view, this is by far the best electronic database available and includes information on FDA approval and black box warnings, mechanism of action, pharmacokinetics, chemical structure, pill photographs, indications, contraindications, adverse effects, dosages, patient education and much more. References in the digital version are also hyperlinked to PubMed.
Assessment:The print version should be on the reference shelf and the digital version on the computer desktop of all practicing pharmacologists, pharmacists, and physicians.

Table of Contents

Sect. IGeneral Principles1
Introduction1
1Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination3
2Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect31
3Principles of Therapeutics45
4Principles of Toxicology and Treatment of Poisoning67
5Gene Therapy81
Sect. IIDrugs Acting at Synaptic and Neuroeffector Junctional Sites113
6Neurotransmission: The Autonomic and Somatic Motor Nervous Systems115
7Muscarinic Receptor Agonists and Antagonists155
8Anticholinesterase Agents175
9Agents Acting at the Neuromuscular Junction and Autonomic Ganglia193
10Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists215
115-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists269
Sect. IIIDrugs Acting on the Central Nervous System291
12Neurotransmission and the Central Nervous System293
13History and Principles of Anesthesiology321
14General Anesthetics337
15Local Anesthetics367
16Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium385
17Hypnotics and Sedatives399
18Ethanol429
19Drugs and the Treatment of Psychiatric Disorders: Depression and Anxiety Disorders447
20Drugs and the Treatment of Psychiatric Disorders: Psychosis and Mania485
21Drugs Effective in the Therapy of the Epilepsies521
22Treatment of Central Nervous System Degenerative Disorders549
23Opioid Analgesics569
24Drug Addiction and Drug Abuse621
Sect. IVAutacoids; Drug Therapy of Inflammation643
Introduction643
25Histamine, Bradykinin, and their Antagonists645
26Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor669
27Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout687
28Drugs Used in the Treatment of Asthma733
Sect. VDrugs Affecting Renal and Cardiovascular Function755
29Diuretics757
30Vasopressin and Other Agents Affecting the Renal Conservation of Water789
31Renin and Angiotensin809
32Drugs Used for the Treatment of Myocardial Ischemia843
33Antihypertensive Agents and the Drug Therapy of Hypertension871
34Pharmacological Treatment of Heart Failure901
35Antiarrhythmic Drugs933
36Drug Therapy for Hypercholesterolemia and Dyslipidemia971
Sect. VIDrugs Affecting Gastrointestinal Function1003
37Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease1005
38Prokinetic Agents, Antiemetics, and Agents Used in Irritable Bowel Syndrome1021
39Agents Used for Diarrhea, Constipation, and Inflammatory Bowel Disease; Agents Used for Biliary and Pancreatic Disease1037
Sect. VIIChemotherapy of Parasitic Infections1059
Introduction1059
40Drugs Used in the Chemotherapy of Protozoal Infections: Malaria1069
41Drugs Used in the Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections1097
42Drugs Used in the Chemotherapy of Helminthiasis1121
Sect. VIIIChemotherapy of Microbial Diseases1141
43Antimicrobial Agents: General Considerations1143
44Antimicrobial Agents: Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections1171
45Antimicrobial Agents: Penicillins, Cephalosporins, and Other [beta]-Lactam Antibiotics1189
46Antimicrobial Agents: The Aminoglycosides1219
47Antimicrobial Agents: Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents1239
48Antimicrobial Agents: Drugs Used in the Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy1273
49Antimicrobial Agents: Antifungal Agents1295
50Antimicrobial Agents: Antiviral Agents (Nonretroviral)1313
51Antimicrobial Agents: Antiretroviral Agents1349
Sect. IXChemotherapy of Neoplastic Diseases1381
Introduction1381
52Antineoplastic Agents1389
Sect. XDrugs Used for Immunomodulation1461
53Immunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants1463
Sect. XIDrugs Acting on the Blood and the Blood-Forming Organs1485
54Hematopoietic Agents: Growth Factors, Minerals, and Vitamins1487
55Anticoagulant, Thrombolytic, and Antiplatelet Drugs1519
Sect. XIIHormones and Hormone Antagonists1539
56Pituitary Hormones and Their Hypothalamic Releasing Factors1541
57Thyroid and Antithyroid Drugs1563
58Estrogens and Progestins1597
59Androgens1635
60Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones1649
61Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas1679
62Agents Affecting Calcification and Bone Turnover: Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds1715
Sect. XIIIThe Vitamins1745
Introduction1745
63Water-Soluble Vitamins: The Vitamin B Complex and Ascorbic Acid1753
64Fat-Soluble Vitamins: Vitamins A, K, and E1773
Sect. XIVDermatology1793
65Dermatological Pharmacology1795
Sect. XVOphthalmology1819
66Ocular Pharmacology1821
Sect. XVIToxicology1849
67Heavy Metals and Heavy-Metals Antagonists1851
68Nonmetallic Environmental Toxicants: Air Pollutants, Solvents and Vapors, and Pesticides1877
App. IPrinciples of Prescription Order Writing and Patient Compliance1903
App. IIDesign and Optimization of Dosage Regimens: Pharmacokinetic Data1917
Index2025

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