Authors: Laurence Brunton
ISBN-13: 9780071422802, ISBN-10: 0071422803
Format: Hardcover
Publisher: McGraw-Hill Companies, The
Date Published: August 2005
Edition: 11st Edition
Laurence L. Brunton, PhD
Professor of Pharmacology and Medicine
University of California, San Diego
Laurence Brunton trained under Alfred Goodman-Gilman and is nationally recognized for his expertise in cell signaling and cardivacular pharmacology. He has published more than 200 original research papers.
John S. Lazo, PhD
Professor and Chairman
Department of Pharmacology
University of Pittsburgh School of Medicine
Under John Lazo's leadership as Chairman, the Department of Pharmacology is regarded as one of the leading academic programs in the United States. He has published extensively in the field of cancer pharmacology.
Keith Parker, MD, PhD
Professor of Internal Medicine and Pharmacology
Division of Endocrinology
Department of Internal Medicine
University of Texas Southwestern School of Medicine
Comprehensive drug reference for students and practitioners. Includes abundant references, illustrations, and a fold-out section on the autonomic nervous system.
Reviewer:Thomas L. Pazdernik, PhD(University of Kansas Medical Center)
Description:The 11th edition of Goodman & Gilman continues to be the most comprehensive and authoritative single source on the pharmacology of drugs. The first edition was published by Alfred Gilman and Louis Goodman in 1941. It soon became known as the bible of pharmacology and, even though editorship and chapter authorships have changed continuously from edition to edition, this remains the gold standard of pharmacology textbooks.
Purpose:The editors have done a remarkable job of condensing information from a rapidly expanding field to slightly reduce the number of pages from the previous edition while adhering to the principles of the original authors and retaining the completeness for which the book is known. The editors have standardized the organization to provide readers with essential physiology and basic pharmacology while providing the kinds of details a physician needs to know under easily identifiable headings. The editors have done a marvelous job in achieving the high standards expected by readers.
Audience:Although this publication may be too extensive for most students to read cover to cover while taking a pharmacology course, it should be a required resource for all who study, research, teach, or practice any facet of healthcare involving the use of medications.
Features:The 11th edition continues to provide the most comprehensive, current, and authoritative information on drugs. This latest version has new chapters on drug transporters, drug metabolism, and pharmacogenetics. The print version comes with a non-transferable subscription to an online digital version. Each drug in the digital version is hyperlinked to Gold Standards, Clinical Pharmacology Online, an online database. PDA downloads are available. In my view, this is by far the best electronic database available and includes information on FDA approval and black box warnings, mechanism of action, pharmacokinetics, chemical structure, pill photographs, indications, contraindications, adverse effects, dosages, patient education and much more. References in the digital version are also hyperlinked to PubMed.
Assessment:The print version should be on the reference shelf and the digital version on the computer desktop of all practicing pharmacologists, pharmacists, and physicians.
Sect. I | General Principles | 1 |
Introduction | 1 | |
1 | Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination | 3 |
2 | Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect | 31 |
3 | Principles of Therapeutics | 45 |
4 | Principles of Toxicology and Treatment of Poisoning | 67 |
5 | Gene Therapy | 81 |
Sect. II | Drugs Acting at Synaptic and Neuroeffector Junctional Sites | 113 |
6 | Neurotransmission: The Autonomic and Somatic Motor Nervous Systems | 115 |
7 | Muscarinic Receptor Agonists and Antagonists | 155 |
8 | Anticholinesterase Agents | 175 |
9 | Agents Acting at the Neuromuscular Junction and Autonomic Ganglia | 193 |
10 | Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists | 215 |
11 | 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists | 269 |
Sect. III | Drugs Acting on the Central Nervous System | 291 |
12 | Neurotransmission and the Central Nervous System | 293 |
13 | History and Principles of Anesthesiology | 321 |
14 | General Anesthetics | 337 |
15 | Local Anesthetics | 367 |
16 | Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium | 385 |
17 | Hypnotics and Sedatives | 399 |
18 | Ethanol | 429 |
19 | Drugs and the Treatment of Psychiatric Disorders: Depression and Anxiety Disorders | 447 |
20 | Drugs and the Treatment of Psychiatric Disorders: Psychosis and Mania | 485 |
21 | Drugs Effective in the Therapy of the Epilepsies | 521 |
22 | Treatment of Central Nervous System Degenerative Disorders | 549 |
23 | Opioid Analgesics | 569 |
24 | Drug Addiction and Drug Abuse | 621 |
Sect. IV | Autacoids; Drug Therapy of Inflammation | 643 |
Introduction | 643 | |
25 | Histamine, Bradykinin, and their Antagonists | 645 |
26 | Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor | 669 |
27 | Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout | 687 |
28 | Drugs Used in the Treatment of Asthma | 733 |
Sect. V | Drugs Affecting Renal and Cardiovascular Function | 755 |
29 | Diuretics | 757 |
30 | Vasopressin and Other Agents Affecting the Renal Conservation of Water | 789 |
31 | Renin and Angiotensin | 809 |
32 | Drugs Used for the Treatment of Myocardial Ischemia | 843 |
33 | Antihypertensive Agents and the Drug Therapy of Hypertension | 871 |
34 | Pharmacological Treatment of Heart Failure | 901 |
35 | Antiarrhythmic Drugs | 933 |
36 | Drug Therapy for Hypercholesterolemia and Dyslipidemia | 971 |
Sect. VI | Drugs Affecting Gastrointestinal Function | 1003 |
37 | Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease | 1005 |
38 | Prokinetic Agents, Antiemetics, and Agents Used in Irritable Bowel Syndrome | 1021 |
39 | Agents Used for Diarrhea, Constipation, and Inflammatory Bowel Disease; Agents Used for Biliary and Pancreatic Disease | 1037 |
Sect. VII | Chemotherapy of Parasitic Infections | 1059 |
Introduction | 1059 | |
40 | Drugs Used in the Chemotherapy of Protozoal Infections: Malaria | 1069 |
41 | Drugs Used in the Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections | 1097 |
42 | Drugs Used in the Chemotherapy of Helminthiasis | 1121 |
Sect. VIII | Chemotherapy of Microbial Diseases | 1141 |
43 | Antimicrobial Agents: General Considerations | 1143 |
44 | Antimicrobial Agents: Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections | 1171 |
45 | Antimicrobial Agents: Penicillins, Cephalosporins, and Other [beta]-Lactam Antibiotics | 1189 |
46 | Antimicrobial Agents: The Aminoglycosides | 1219 |
47 | Antimicrobial Agents: Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents | 1239 |
48 | Antimicrobial Agents: Drugs Used in the Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy | 1273 |
49 | Antimicrobial Agents: Antifungal Agents | 1295 |
50 | Antimicrobial Agents: Antiviral Agents (Nonretroviral) | 1313 |
51 | Antimicrobial Agents: Antiretroviral Agents | 1349 |
Sect. IX | Chemotherapy of Neoplastic Diseases | 1381 |
Introduction | 1381 | |
52 | Antineoplastic Agents | 1389 |
Sect. X | Drugs Used for Immunomodulation | 1461 |
53 | Immunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants | 1463 |
Sect. XI | Drugs Acting on the Blood and the Blood-Forming Organs | 1485 |
54 | Hematopoietic Agents: Growth Factors, Minerals, and Vitamins | 1487 |
55 | Anticoagulant, Thrombolytic, and Antiplatelet Drugs | 1519 |
Sect. XII | Hormones and Hormone Antagonists | 1539 |
56 | Pituitary Hormones and Their Hypothalamic Releasing Factors | 1541 |
57 | Thyroid and Antithyroid Drugs | 1563 |
58 | Estrogens and Progestins | 1597 |
59 | Androgens | 1635 |
60 | Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones | 1649 |
61 | Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas | 1679 |
62 | Agents Affecting Calcification and Bone Turnover: Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds | 1715 |
Sect. XIII | The Vitamins | 1745 |
Introduction | 1745 | |
63 | Water-Soluble Vitamins: The Vitamin B Complex and Ascorbic Acid | 1753 |
64 | Fat-Soluble Vitamins: Vitamins A, K, and E | 1773 |
Sect. XIV | Dermatology | 1793 |
65 | Dermatological Pharmacology | 1795 |
Sect. XV | Ophthalmology | 1819 |
66 | Ocular Pharmacology | 1821 |
Sect. XVI | Toxicology | 1849 |
67 | Heavy Metals and Heavy-Metals Antagonists | 1851 |
68 | Nonmetallic Environmental Toxicants: Air Pollutants, Solvents and Vapors, and Pesticides | 1877 |
App. I | Principles of Prescription Order Writing and Patient Compliance | 1903 |
App. II | Design and Optimization of Dosage Regimens: Pharmacokinetic Data | 1917 |
Index | 2025 |