Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods »

Debasis Bagchi, Ph.D., Adjunct Professor of Medicinal Chemistry, Pharmacological and Pharmaceutical Sciences Department, University of Houston, TX.

Francis Lau, InterHealth USA, Benecia, CA.

Manashi Bagchi, Ph.D., InterHealth USA, Benecia, CA.

The nutraceutical and functional food field is rapidly growing in diverse sectors, including academic, commercial and government. This has brought a corresponding shift in research focus and in public awareness. Understanding the relevance of the scientific principles in determining the safety and effectiveness of functional foods and nutraceuticals is increasingly important. It is becoming increasingly evident that genomic research technologies will be used in the coming years and there is a need to provide resources that will facilitate this growth. This book incorporates the most recent advances in the three major sectors of the field within one volume. Genomics, proteomics, and metobolomics represent three major scientific research areas that contribute to nutraceutical and functional food research for studies of effectiveness and safety.

Editors and Contributors

Preface

Section 1 Introduction

1 Recent advances in nutraceuticals and functional foods Manashi Bagchi Bagchi, Manashi 3

2 Novel omics technologies in nutraceutical and functional food research Kaijun Xiao Xiao, Kaijun 11

Section 2 Genomics

3 Nutrigenomics and statistical power: The ethics of genetically informed nutritional advice Ruth Chadwick Chadwick, Ruth 23

4 NutrimiRomics: The promise of a new discipline in nutrigenomics Chandan K. Sen Sen, Chandan K. 35

5 Genomics in weight loss nutraceuticals Shirley Zafra-Stone Zafra-Stone, Shirley 45

6 Application of genomics and bioinformatics analysis in exploratory study of functional food Aiko Manji Manji, Aiko 61

7 Genomics as a tool to characterize anti-inflammatory nutraceuticals Sashwati Roy Roy, Sashwati 73

8 Application of nutrigenomics in gastrointestinal health Donald R. Love Love, Donald R. 83

9 Genomics analysis to demonstrate the safety and efficacy of dietary antioxidants Nilanjana Maulik Maulik, Nilanjana 95

10 Genomics applied to nutrients and functional foods in Japan: State of the art Keiko Abe Abe, Keiko 127

11 Genomic basis of anti-inflammatory properties of Boswellia extract Krishanu Sengupta Sengupta, Krishanu 155

12 Nutrigenomic Perspectives on Cancer Chemoprevention with Anti-inflammatory and Antioxidant Phytochemicals: NF-kB and Nrf2 Signaling Pathways as Potential Targets Young-Joon Surh Surh, Young-Joon 175

Section 3 Proteomics

13 Proteomics analysis of the functionality of Toona sinensis by 2D-gel electrophoresis Chun-Yung Huang Huang, Chun-Yung 201

14 Application of proteomics in nutrition research Baukje de Roos de Roos, Baukje 213

15 Proteomics approach to assess the potency of dietary grape seed proanthocyanidins Hai-Qing Gao Gao, Hai-Qing 225

16 Proteomics and its application for elucidating insulin deregulation in diabetes Chan-Wha Kim Kim, Chan-Wha 241

Section 4 Metabolomics

17 NMR-based-metabolomics strategy for the classification and quality control of nutraceuticals and functional foods Huiru Tang Tang, Huiru 265

18 Metabolomics: An emerging post-genomic tool for nutrition Jennifer Kirwan Kirwan, Jennifer 271

19 Evaluation of the beneficial effects of phytonutrients by metabolomics Silas G. Villas-Boas Villas-Boas, Silas G. 287

Section 5 Nutrigenomics in Human Health

20 Omics for the development of novel phytomedicines Ning-Sun Yang Yang, Ning-Sun 299

21 Contribution of omics revolution to cancer prevention research John A. Milner Milner, John A. 315

Index 329