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Cytokines and Cancer »

Book cover image of Cytokines and Cancer by Leonidas C. Platanias

Authors: Leonidas C. Platanias
ISBN-13: 9780387243603, ISBN-10: 0387243607
Format: Hardcover
Publisher: Springer-Verlag New York, LLC
Date Published: December 2009
Edition: (Non-applicable)

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Author Biography: Leonidas C. Platanias

Book Synopsis

This book is a comprehensive review of the current knowledge on cytokines and cancer. Cytokines play a variety of roles in cancer, both as components of pathogenetic mechanisms, as well as agents used in the treatment of certain malignancies. To date, there has not been a book that covers both basic science and translational/clinical research in the field of cytokines in malignancies. This book is written by leading figures in the field of cytokine biology and cytokine therapeutics and is specifically focused on this subject. The book is divided into two parts. The first part is focused on current developments in the basic science field. There is a particular emphasis on novel mechanisms of cytokine actions in malignant cells. The second part deals with translational and clinical research in the field, and many of the authors of these chapters were among the first to introduce several cytokines in the treatment of certain tumors.

Collectively, the information provided in this book will be helpful to people in the medical field at several levels, including medical students, interns, residents, clinical and basic science researchers, as well as oncologists in practice.

Table of Contents

1Polypeptide growth factors and their receptors1
2Chemokines and cancer15
3Interferons45
4Cytokines and lymphomas71
5Pro-apototic and anti-apoptotic effects of tumor necrosis factor in tumor cells105
6Transforming growth factor beta and breast cancer131
7Transforming growth factor beta in prostate cancer159
8Angiostatin177
9Interferons in the treatment of solid tumors209
10Targeting cytokine receptors and pathways in the treatment of breast cancer243
11Interleukin-2 in the treatment of renal cell carcinoma and malignant melanoma263
12Cytokine targeted treatments for lung cancer289
13Cytokines in the treatment of acute leukemias313
14Cytokines in hematopoietic stem cell transplantation333
15Novel cytokines in the treatment of malignancies353

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