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Classics in Total Synthesis: Targets, Strategies, Methods » (1st Edition)

Book cover image of Classics in Total Synthesis: Targets, Strategies, Methods by K. C. Nicolaou

Authors: K. C. Nicolaou, E. J. Sorensen
ISBN-13: 9783527292318, ISBN-10: 3527292314
Format: Paperback
Publisher: Wiley, John & Sons, Incorporated
Date Published: December 1996
Edition: 1st Edition

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Author Biography: K. C. Nicolaou

Book Synopsis

K. C. Nicolaou, E. J. Sorensen Classics in Total Synthesis Targets, Strategies, Methods This book is a must for every synthetic organic chemist. With didactic skill and clarity, K. C. Nicolaou and E. J. Sorensen present the most remarkable and ingenious total syntheses from the laboratories of some of the world’s greatest synthetic organic chemists. To make the strategies more understandable and accessible, especially to the novice, each total synthesis is first analyzed retrosynthetically. The authors then carefully describe each step and comment on alternative methods and potential pitfalls. When appropriate, key chemical reactions are discussed in the wider context of the chemical literature, giving the reader a lesson in both total synthesis and synthetic methods. Diverse structural types of natural products and important organic transformations including pericyclic, ionic, radical, and photochemical reactions are covered. Catalysis, asymmetric synthesis, organometallic chemistry, and cyclization reactions are especially highlighted. Mechanism, reactivity, selectivity, and stereochemistry are presented clearly and discussed analytically. Numerous references to useful reviews and the original literature will make this book the first point of entry into the vast field of synthetic organic chemistry. Special emphasis is placed on the skillful use of graphics and schemes. Retrosynthetic analyses, reaction sequences and crucial synthetic steps are presented in boxed, blue background sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students, teachers, and researchers alike will find this book to be a gold mine of useful information. Every synthetic chemist will have a copy on his or her desk.

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Table of Contents

Ch. 1Introduction: Constructing the Molecules of Nature
Ch. 2Strychnine
Ch. 3Penicillin V
Ch. 4Reserpine
Ch. 5Prostaglandin [actual symbol not reproducible] and Prostaglandin E[subscript 2] (PGE[subscript 2])
Ch. 6Progesterone
Ch. 7Carpanone
Ch. 8Vitamin B[subscript 12]
Ch. 9Prostaglandin A[subscript 2] (PGA[subscript 2]) and Prostaglandin [actual symbol not reproducible]
Ch. 10Estrone
Ch. 11Erythronolide B
Ch. 12Monensin
Ch. 13Periplanone B
Ch. 14Isocomene
Ch. 15Monensin
Ch. 16Thienamycin
Ch. 17Endiandric Acids A-D
Ch. 18Biotin
Ch. 19L-Hexoses
Ch. 20Asteltoxin
Ch. 21Periplanone B
Ch. 22Menthol
Ch. 23Hirsutene and [actual symbol not reproducible]
Ch. 24Amphoteronolide B and Amphotericin B
Ch. 25Ginkgolide B
Ch. 26Methyl Homosecodaphniphyllate
Ch. 27Indolizomycin
Ch. 28Cytovaricin
Ch. 29Gilvocarcin M and Gilvocarcin V
Ch. 30Calicheamicin [actual symbol not reproducible]
Ch. 31Rapamycin
Ch. 32Paeoniflorigenin and Paeoniflorin
Ch. 33Strychnine
Ch. 34Taxol
Ch. 35Zaragozic Acid A/Squalestatin SI
Ch. 36Palytoxin
Ch. 37Brevetoxin B
Author Index
Subject Index

Subjects