Authors: John Leonard, Garry Procter, Barry Lygo, Barry Lygo
ISBN-13: 9780748740710, ISBN-10: 0748740716
Format: Paperback
Publisher: Taylor & Francis, Inc.
Date Published: June 1994
Edition: 2nd Edition
The first edition of this book achieved considerable success due to its ease of use and practical approach, and to the clear writing style of the authors. The preparation of organic compounds is still central to many disciplines, from the most applied to the highly academic and, more tan ever is not limited to chemists. With an emphasis on the most up-to-date techniques commonly used in organic syntheses, this book draws on the extensive experience of the authors and their association with some of the world's mleading laboratories of synthetic organic chemistry. In this new edition, all the figures have been re-drawn to bring them up to the highest possible standard, and the text has been revised to bring it up to date.
Written primarily for postgraduate, advanced undergraduate and industrial organic chemists, particularly those involved in pharmaceutical, agrochemical and other areas of fine chemical research, the book is also a source of reference for biochemists, biologists, genetic engineers, material scientists and polymer researchers.
A guide to the preparation of organic compounds and types of reactions used in modern organic synthesis, emphasizing recent techniques. Covers lab basics such as safety, record keeping, and equipment, presents techniques for working with solvents, reagents, gases, and vacuum pumps, and details carrying out reactions, purification, and characterization. Includes a review of the chemical literature, and appendices listing properties of solvents, gases, reducing reagents, and oxidizing reagents. For postgraduates and advanced undergraduates. Annotation c. Book News, Inc., Portland, OR (booknews.com)
1 | General Introduction | 1 |
2 | Safety | 3 |
3 | Keeping records of laboratory work | 8 |
4 | Equipping the laboratory and the bench | 36 |
5 | Purification and drying of solvents | 54 |
6 | Reagents: Preparation, purification and handling | 69 |
7 | Gases | 107 |
8 | Vacuum pumps | 122 |
9 | Carrying out the reaction | 128 |
10 | Working up the reaction | 177 |
11 | Purification | 184 |
12 | Small scale reactions | 227 |
13 | Large scale reactions | 236 |
14 | Special procedures | 240 |
15 | Characterization | 250 |
16 | 'Trouble shooting'; what to do when things don't work | 258 |
17 | The chemical literature | 262 |
Appendix 1. Properties of common solvents | 277 | |
Appendix 2. Properties of common gases | 278 | |
Appendix 3. Approximate pKa values for some common deprotonations compared to some common bases | 279 | |
Appendix 4. Lewis acids | 280 | |
Appendix 5. Common reducing reagents | 281 | |
Appendix 6. Common oxidizing reagents | 285 | |
Index | 289 |